Journal
/
Quimica
/
A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
JoVE Revista
Quimica
Se requiere una suscripción a JoVE para ver este contenido.  Inicie sesión o comience su prueba gratuita.
JoVE Revista Quimica
A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor

DOI:
10.3791/64937-v

•

05:21 min

•

February 10, 2023

•

, , , , ,
1Shenzhen Hwagen Pharmaceutical Co., Ltd, 2Guangdong Raffles Pharmaceutical Technology Co., Ltd

Capítulos

  • 00:04Introduction
  • 00:46Continuous Flow Equipment Setup, Safety Check, and Leak Test
  • 02:29Continuous Flow Reaction Process
  • 03:29Results: Effect of Temperature and Residence Time on Continuous Flow Reaction
  • 04:33Conclusion

Summary

Traducción Automática

Traducción Automática

A detailed scalable continuous flow protocol is presented to synthesize an aryl fluoride from an aryl amine through the Balz-Schiemann reaction.

Tags

Balz-Schiemann ReactionContinuous Flow ReactorAryl FluorideAryl AmineFine Chemical IndustryPharmaceutical IndustryMicroflow ReactorDynamic Mixing Tube ReactorTemperature RegulationSafetyLeakage CheckSteady State EquilibriumProduct Collection

Article

Embed

Añadir a la lista de reproducción

Usage Statistics

Videos relacionados

Preparation and Use of Samarium Diiodide (SmI2) in Organic Synthesis: The Mechanistic Role of HMPA and Ni(II) Salts in the Samarium Barbier Reaction

Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry (UPLC-HRMS)

A Simple and Rapid Protocol for Measuring Neutral Lipids in Algal Cells Using Fluorescence

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example

Post Column Derivatization Using Reaction Flow High Performance Liquid Chromatography Columns

Synthesis and Exfoliation of Discotic Zirconium Phosphates to Obtain Colloidal Liquid Crystals

A Protocol for Safe Lithiation Reactions Using Organolithium Reagents

A Protocol for Electrochemical Evaluations and State of Charge Diagnostics of a Symmetric Organic Redox Flow Battery

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid

Combustion Chemistry of Fuels: Quantitative Speciation Data Obtained from an Atmospheric High-temperature Flow Reactor with Coupled Molecular-beam Mass Spectrometer

Read Article