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Journal / Bioengineering / Sonodynamisk terapi til behandling af glioblastom …
JoVE Journal
Bioengineering

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JoVE Journal Bioengineering
Sonodynamisk terapi til behandling af glioblastom multiforme i en musemodel ved hjælp af et bærbart bordfokuseret ultralydssystem
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Sonodynamisk terapi til behandling af glioblastom multiforme i en musemodel ved hjælp af et bærbart bordfokuseret ultralydssystem

Article DOI: 10.3791/65114-v • 09:07 min • February 10th, 2023
February 10th, 2023 •
1,2, 1,2, 3, 1,2, 4, 1, 1, 5, 1, 1,2,4,6,7
1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Biomedical Engineering, Johns Hopkins University, 3Krieger School of Arts and Sciences, Johns Hopkins University, 4Department of Electrical Engineering and Computer Science, Johns Hopkins University, 5Department of Radiology, Cancer Imaging Division, Johns Hopkins University School of Medicine, 6Department of Mechanical Engineering, Johns Hopkins University, 7Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine

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Her beskriver vi en protokol, der beskriver, hvordan man udfører sonodynamisk terapi i en in vivo museglioblastommodel ved hjælp af magnetisk resonansstyret fokuseret ultralyd.

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Sonodynamisk terapi glioblastom multiforme musemodel fokuseret ultralydssystem Sonosensibiliserende middel øget følsomhed kliniske behandlinger langsigtede overlevelsesrater ikke-invasiv behandling tumorspecifik behandling Sonosensibilisatorer Reaktive oxidative arter Apoptose Standardiserede parametre Prækliniske undersøgelser Terapeutisk strategioptimering Præklinisk GBM gnavermodel Magnetisk resonansstyret FUS (MRgFUS) Specifik målretning Hjernetumor Benchtop-enhed
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