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Bioengineering

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JoVE Journal Bioengineering
Sonodynamisk terapi for behandling av glioblastom multiforme i en musemodell ved bruk av et bærbart benkefokusert ultralydsystem
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Sonodynamisk terapi for behandling av glioblastom multiforme i en musemodell ved bruk av et bærbart benkefokusert ultralydsystem

Article DOI: 10.3791/65114-v • 09:07 min • February 10th, 2023
February 10th, 2023 •
1,2, 1,2, 3, 1,2, 4, 1, 1, 5, 1, 1,2,4,6,7
1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Biomedical Engineering, Johns Hopkins University, 3Krieger School of Arts and Sciences, Johns Hopkins University, 4Department of Electrical Engineering and Computer Science, Johns Hopkins University, 5Department of Radiology, Cancer Imaging Division, Johns Hopkins University School of Medicine, 6Department of Mechanical Engineering, Johns Hopkins University, 7Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine

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Her beskriver vi en protokoll som beskriver hvordan du utfører sonodynamisk terapi i en in vivo musglioblastommodell ved hjelp av magnetisk resonansstyrt fokusert ultralyd.

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Sonodynamisk terapi glioblastom multiforme musemodell fokusert ultralydsystem Sonosensibiliserende middel økt sensitivitet kliniske behandlinger langtidsoverlevelse ikke-invasiv behandling tumorspesifikk behandling Sonosensibilisatorer reaktive oksidative arter apoptose standardiserte parametere prekliniske studier terapeutisk strategioptimalisering preklinisk GBM gnagermodell magnetisk resonansstyrt FUS (MRgFUS) spesifikk målretting hjernesvulst stasjonær enhet
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