Perfilado fenotípico de fenotipos conductuales tipo parkinsoniano inducidos por MPTP en larvas de pez cebra basado en un experimento conductual
1.8K visualizaciones
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10:33 min.
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15 de mayo de 2026
DOI :10.3791/70041-v
15 de mayo de 2026
•1.8K visualizaciones
Zhuang Miao1 , Jiying Bi1 , Jie Zhang2,3 , Min Tian4 , Zhuoran Yan4 , Ruonan Duan4 , Ning Wang2,3 , Xiang Li1,5,6
1Department of Medicinal Chemistry, State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 2College of Information Engineering, Ningde Normal University, 3Digital Fujian Research Institute of Big Data for Elderly Rehabilitation and Nursing, 4Department of Neurology, Qilu Hospital Cheeloo College of Medicine, Shandong University, 5Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, 6Jinan Microecological Biomedicine Shandong Laboratory
Este protocolo establece un paradigma de fenotipado conductual en larvas de pez cebra tratadas con MPTP para evaluar déficits motores y no motores similares a la enfermedad de Parkinson.
Chapters in this video
0:00
Introduction
0:26
Zebrafish Embryo Preparation for Behavioral Assessment
1:44
Sleep‑Wake Behavioral Analysis of Zebrafish Larvae Using Zebrabox System
3:39
Assessment of Photomotor Response
4:35
Assessment of Thigmotaxis
5:23
Evaluation of Locomotor Activity
5:52
Startle Response Test
7:18
Light‑Dark Challenge Assay
8:24
Results
9:54
Conclusion
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