Low Fluid Shear
Low Fluid Shear - Related Videos
09:20
The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress
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Cited by 10 •
2016
Different levels and patterns of fluid shear are known to modulate endothelial gene expression, phenotype and susceptibility to disease. We discuss the assembly and use of 'shear rings': a model that produces unidirectional, periodic shear stress patterns. Shear rings are simple to assemble, economical and can produce high cell yields.
10:28
Experimental Measurement of Settling Velocity of Spherical Particles in Unconfined and Confined Surfactant-based Shear Thinning Viscoelastic Fluids
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Cited by 15 •
2014
This paper demonstrates the experimental procedure to measure terminal settling velocities of spherical particles in surfactant-based shear thinning viscoelastic fluids. Fluids over a wide range of rheological properties are prepared and settling velocities are measured for a range of particle sizes in unbounded fluids and fluids between parallel walls.
07:26
Agarose Fluid Gels Formed by Shear Processing During Gelation for Suspended 3D Bioprinting
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Cited by 6 •
2023
Shear processing during hydrogel formation results in the production of microgel suspensions that shear-thin but rapidly restructure following the removal of shear forces. Such materials have been used as a supporting matrix for bioprinting complex, cell-laden structures. Here, methods used to manufacture the supporting bed and compatible bioinks are described.
04:53
A Novel Capsulorhexis Technique Using Shearing Forces with Cystotome
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Cited by 5 •
2010
This video demonstrates a novel capsulorhexis technique in modern cataract surgery. Capsulorhexis is the most difficult and important part of phacoemulsification surgery.
01:18
Shearing Stress
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2026
Shearing stress, denoted by the Greek letter tau (τ), is stress caused by forces acting transversely on an object. These forces create internal ones within the entity in the plane where the external forces are applied. The resultant of these internal forces is the shear in the section. The average shearing stress can be calculated by dividing the shear by the area of the cross-section. However, this is an average value as the distribution of shearing stress across a section varies. It can...
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Researchers characterize the condition through fluid viscosity and velocity gradients, because both affect the shear stress imposed on a surface. A system with relatively small tangential force therefore reflects a combination of fluid properties and flow behavior rather than a cell-only state. Tracking these variables helps interpret why two biological flow environments may produce different cellular responses.
Cells can modify their cytoskeletal organization and adhesion when exposed to low fluid shear. The cytoskeleton provides internal structural organization, while adhesion connects cells with surrounding surfaces or neighboring cells. Examining both responses helps researchers determine how cells adjust their physical interactions and growth behavior within slowly moving or poorly perfused environments.
Mechanotransduction signaling allows cells to respond to changes in physical forces rather than only to chemical conditions. Under low fluid shear, altered signaling can accompany changes in adhesion and cytoskeletal organization, linking the flow environment to cellular behavior. Studying this connection helps explain how biological systems interpret weak mechanical cues in vessels and laboratory flow models.
Researchers can investigate the condition in vessels, laboratory flow systems, and microfluidic environments where fluid movement produces controlled physical cues. They can then examine changes in cytoskeletal organization, adhesion, mechanotransduction signaling, or cell growth. Comparing these cellular outcomes across flow settings helps connect the measured fluid environment with biological responses.
These experiments can clarify how endothelial cells respond to weak mechanical stimulation in vessel-like environments. Measurements or observations may focus on cytoskeletal organization, adhesion, mechanotransduction signaling, and growth. Such findings help connect physical flow conditions with endothelial behavior and provide biological context for studying how vessel-associated cells respond to their surrounding fluid.
Low fluid shear is useful when researchers need to study cells or engineered tissues in slowly flowing laboratory environments. Microfluidic systems provide a setting for examining how weak flow-related forces influence cellular organization, adhesion, signaling, and growth. In tissue engineering, these observations can help evaluate how physical flow cues relate to the behavior of developing biological constructs.
Because weak flow can represent slowly moving or poorly perfused conditions, researchers use it to investigate cellular behavior in environments where transport processes differ from those in more actively flowing systems. The approach supports studies of cell growth, mechanotransduction, and adhesion while also helping examine how flow conditions shape biological niches in vessels and engineered systems.