Kidney Marrow Cells
Kidney Marrow Cells - Related Videos
08:42
Transplantation of Whole Kidney Marrow in Adult Zebrafish
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Cited by 17 •
2007
In this article, we demonstrate a method to perform HCT in adult zebrafish.
06:04
Transplantation of Cells Directly into the Kidney of Adult Zebrafish
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Cited by 10 •
2011
Cell transplantation is an essential technique for studying tissue regeneration and for developing cell-based therapies of disease. We demonstrate here a microsurgical technique that permits the transplantation of genetically labeled cells directly into the kidney of adult zebrafish fish.
03:56
Bone Marrow Aspiration: A Method to Obtain Bone Marrow to Examine Cell Morphology
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2023
This video describes the technique of aspirating bone marrow from iliac spine and smear preparation for biopsy. In the example, we perform bone marrow aspiration from an acute myeloid leukemia (AML) patient and examine the cells to check for measurable residual disease (MRD), an important prognostic biomarker.
09:15
Reliable and High Efficiency Extraction of Kidney Immune Cells
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Cited by 12 •
2016
Techniques that are reliable and efficient for the isolation of kidney immune cells are needed for downstream applications. This requires surface antibody labeling of a small number of kidney immune cells. Herein, we describe a concise method for isolation of kidney immune cells that seemingly achieves this goal.
02:57
Bone Marrow-Derived Dendritic Cells Generation: A Method to Generate Dendritic Cells from Mouse Bone Marrow
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2023
This video describes a protocol for the generation of dendritic cells--key antigen-presenting cells that activate T cells--from the bone marrow of an adult mouse.
FAQs
Recruitment begins when bone marrow-derived cells circulate through the bloodstream and encounter kidney-associated signals. In kidney cancer research, inflammatory or tumor-associated cues can influence whether these cells migrate toward renal tissue, remain there, or interact with nearby cells. Tracking this movement helps investigators connect systemic hematopoietic responses with local changes in the kidney tumor microenvironment.
Once present in kidney tissue, these cells can release signaling molecules and respond to cues produced during inflammation or by tumors. This two-way communication may alter interactions among hematopoietic, renal, immune, and cancer cells. Recruitment alone does not describe their function; the signals exchanged help explain associations with tissue remodeling, tumor growth, metastasis, and treatment response.
Researchers can distinguish three biologically different observations: cells may be detected while circulating, located within kidney tissue, or newly recruited in response to a local cue. Separating these states clarifies whether an observed effect reflects delivery, persistence, or active response. That distinction is useful when interpreting kidney tumor inflammation, remodeling, growth, metastasis, or treatment response.
Studies can focus on two linked questions: which conditions attract these cells to renal tissue, and what they do after arrival. Investigators can then examine their interactions with renal, immune, and cancer cells and relate those observations to tumor-associated inflammation, tissue remodeling, or therapeutic response. This framework connects cell behavior with tumor-microenvironment outcomes.
Within experimental kidney cancer models, these cells provide a way to examine how hematopoietic components shape the tumor microenvironment. Researchers can compare recruitment or local behavior with changes in inflammation, remodeling, tumor growth, metastasis, or treatment response. Such models are valuable because they connect cellular interactions to broader disease-associated outcomes rather than treating tumor cells in isolation.
Findings from this area can guide therapies aimed at interactions between tumors and surrounding cells, rather than focusing only on cancer cells themselves. Relevant targets may include recruitment, signaling, or communication among hematopoietic, renal, immune, and cancer cells. In cancer research, this perspective supports strategies designed to modify the tumor microenvironment and treatment response.