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Transplantation of Whole Kidney Marrow in Adult Zebrafish

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Biology

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Transplantation of Whole Kidney Marrow in Adult Zebrafish

Transplantation of Whole Kidney Marrow in Adult Zebrafish

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14,376 Views

08:42 min

February 25, 2007

DOI: 10.3791/159-v

Jocelyn LeBlanc¹, Teresa Venezia Bowman¹, Leonard Zon¹

¹Children's Hospital, Harvard Stem Cell Institute,Harvard Medical School

In this article, we demonstrate a method to perform HCT in adult zebrafish.

My name is Jocelyn Blank. I'm a technician in Lauren Z's lab And so I'm studying hematopoiesis and zebrafish. So we're trying to learn more about hematopoiesis especially.

So this is a general hematopoiesis sort of schematic. And so you start with a long term meta stem cell which can self-renew and it can also make a short term stem cell, which then can make progenitors a lymphoid progenitor and a myeloid progenitor. And then these respectively make lymphoid or myeloid cells.

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Transplantation Whole Kidney Marrow Adult Zebrafish Hematopoietic Stem Cells (HSC)Blood Lineages Transplanted Cell Irradiated Recipient HCT (hematopoietic Cell Transplantation)Reverse Genetic Manipulations Regulatory Factors HSC Biology Zebrafish Model Genetic And Chemical Screening Methodologies Adult Hematopoiesis Donor Cells Intracardiac Injection Post-transplant Care

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