Solid Organic Compounds

Solid organic compounds are carbon-containing substances that exist as solids under specified conditions, making their structure, purity, and physical properties important in chemistry. Their behavior arises from molecular arrangement in a crystal lattice and intermolecular forces such as hydrogen bonding, dipole interactions, and dispersion forces, which influence melting point, solubility, stability, and polymorphism. Chemists characterize these compounds through melting-point analysis, crystallization, spectroscopy, and other methods to identify substances and assess purity. Solid organic compounds are central to pharmaceuticals, dyes, polymers, agrochemicals, and materials research, where controlling crystal form can affect processing, performance, and biological activity.

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JoVE Core - Chemistry

Organic Compounds

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2020

All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...

Solid-Liquid Extraction

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2023

Source: Laboratory of Dr. Jay Deiner — City University of New York Extraction is a crucial step in most chemical analyses. It entails removing the analyte from its sample matrix and passing it into the phase required for spectroscopic or chromatographic identification and quantification. When the sample is a solid and the required phase for analysis is a liquid, the process is called solid-liquid extraction. A simple and broadly applicable form of solid-liquid extraction entails combining the...

Solid Phase Synthesis

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2023

Source: Vy M. Dong and Diane Le, Department of Chemistry, University of California, Irvine, CA Merrifield's solid-phase synthesis is a Nobel Prize winning invention where a reactant molecule is bound on a solid support and undergoes successive chemical reactions to form a desired compound. When the molecules are bound to a solid support, excess reagents and byproducts can be removed by washing away the impurities, while the target compound remains bound to the resin. Specifically, we will...

Education

JoVE Science Education - Chemistry
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Purifying Compounds by Recrystallization

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2023

Source: Laboratory of Dr. Jimmy Franco - Merrimack College Recrystallization is a technique used to purify solid compounds.1 Solids tend to be more soluble in hot liquids than in cold liquids. During recrystallization, an impure solid compound is dissolved in a hot liquid until the solution is saturated, and then the liquid is allowed to cool.2 The compound should then form relatively pure crystals. Ideally, any impurities that are present will remain in the solution and will not be...

Research

JoVE Journal - Chemistry

Magnetometric Characterization of Intermediates in the Solid-State Electrochemistry of Redox-Active Metal-Organic Frameworks

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2023

Ex situ magnetic surveys can directly provide bulk and local information on a magnetic electrode to reveal its charge storage mechanism step by step. Herein, electron spin resonance (ESR) and magnetic susceptibility are demonstrated to monitor the evaluation of paramagnetic species and their concentration in a redox-active metal-organic framework (MOF).

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