Blast Exposure Mice
Blast Exposure Mice - Related Videos
06:00
Modeling Highly Repetitive Low-level Blast Exposure in Mice
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Cited by 1 •
2024
Presented here are methods for producing repeated low-intensity blast exposures using mice.
06:20
Generation of Warfighter Avatars from Weapon Training Scene Images for Blast Exposure Simulations
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Cited by 1 •
2024
A computational framework was developed to automatically reconstruct virtual scenes comprising 3D avatars of soldiers using image and/or video data. The virtual scenes help estimate blast overpressure exposure during weapon training. The tool facilitates a realistic representation of human posture in blast exposure simulations in various scenarios.
09:41
Blast Quantification Using Hopkinson Pressure Bars
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Cited by 2 •
2016
This protocol details the use of Hopkinson pressure bars to measure reflected blast loading from near-field explosive events. It is capable of interpolating a pressure-time history at any point on a reflective boundary and as such can be used to fully characterize the spatial and temporal variations in loading produced.
10:51
Evaluating Primary Blast Effects In Vitro
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Cited by 12 •
2017
Understanding how cells are modulated by exposure to shock waves can help identify the mechanisms behind injuries triggered from blast events. This protocol uses custom-built shock tube equipment to apply shock waves at a range of pressures to cell monolayers and to identify the subsequent effects on cell viability.
02:40
Induction and Evaluation of Depression in Mice Through Chronic Stress Exposure
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2025
Source: Yan, Z., et al. Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice. J. Vis. Exp. (2019).The video demonstrates the process of establishing a mouse model of chronic stress-induced depression and assessing depressive behaviors. The chronic application of various stressors triggers the release of corticosterone, leading to neuronal over-excitation and eventual neuronal death, which results in depression-like symptoms in the mice.
FAQs
A defined pressure wave gives researchers a controlled exposure condition that can be related to later nervous-system changes. By comparing animals exposed to different injury severities or examined at different times, investigators can evaluate how exposure conditions correspond with cognitive or motor deficits, neuropathology, inflammation, and other physiological responses.
Severity and timing are central comparison variables. Severity allows investigators to examine whether stronger or weaker exposure conditions are associated with different neural, behavioral, or physiological outcomes. Timing adds a temporal dimension, helping researchers observe how responses change after exposure rather than treating injury as a single unchanging event. These comparisons support interpretation of treatment effects.
No single measurement captures the full response. Neural-tissue assessment addresses neuropathology, behavioral testing can reveal cognitive or motor deficits, and inflammatory or other physiological measures provide complementary evidence of nervous-system responses. Using these outcome categories together helps connect observable function with underlying biological changes in the model.
The model supports controlled comparisons in which exposure severity, examination timing, or treatment condition can vary across groups. Researchers can then relate those differences to changes in neural tissue, behavior, inflammation, and other physiological outcomes. This design helps distinguish effects associated with the exposure from changes associated with when or how animals are assessed.
A study first applies a defined pressure-wave exposure, followed by assessments conducted at selected times. Researchers may examine neural tissue, behavior, inflammation, and other physiological responses, then compare the findings across exposure conditions or treatment groups. This workflow links the experimental exposure to measurable changes in nervous-system structure and function.
Blast exposure mice can contribute to research on injury mechanisms, biomarker development, and potential interventions. Injury mechanisms are investigated by relating exposure conditions to neuropathology and functional deficits. Biomarker studies can use the resulting tissue or physiological changes, while intervention research can compare outcomes across treatment conditions. These applications support work relevant to service members and civilians.