Neonatal Mouse Inner Ear
Neonatal Mouse Inner Ear - Related Videos
03:52
Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse
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Cited by 37 •
2018
In this study, we describe the posterior semicircular canal approach as a reliable method for inner ear gene delivery in neonatal mice. We show that gene delivery through the posterior semicircular canal is able to perfuse the entire inner ear.
07:50
Isolation and Culture of Neonatal Mouse Cardiomyocytes
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Cited by 187 •
2013
Primary mouse cardiomyocyte cultures are one of the pivotal tools for the investigation of myofibrillar organization and function. The following protocol describes the isolation and culture of primary cardiomyocytes from neonatal mouse hearts. The resulting cardiomyocyte cultures may be subsequently used for a variety of biomechanical, biochemical and cell-biological assays.
02:53
Neonatal Mouse Ovary Isolation: A Surgical Procedure to Harvest Pair of Ovaries from Neonatal Mouse Model
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2025
In this video, we describe a surgical procedure to isolate ovaries from a neonatal mouse.
04:36
Canalostomy for Local Drug Delivery into the Inner Ear of an Adult Mouse
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2025
This video showcases canalostomy, a procedure that allows local drug delivery into the inner ear of a mouse through the semicircular canal with minimal damage to hearing and vestibular function. This method enables the inoculation of viral vectors, pharmaceuticals, and small molecules into the mouse's inner ear.
03:58
Apical Resection Neonatal Mouse Model: A Surgical Procedure to Amputate the Ventricular Apex to Study Regenerative Potential in a Neonate Mouse Heart
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2025
In this video, we demonstrate the procedure to surgically remove the left ventricular apex of a neonatal mouse heart.
FAQs
Mechanical movement is converted into electrical signals by cochlear and vestibular hair cells. This sensory conversion links physical motion with activity that can be processed by the nervous system. Studying it during early postnatal development helps researchers determine how hearing and balance signals emerge as the sensory organs and their associated neurons mature.
Supporting cells and neurons mature alongside hair cells through coordinated genetic and cellular processes. Their development is important because sensory detection depends on more than hair cells alone: the surrounding cellular environment and neural elements must also develop appropriately. Examining these relationships helps reveal how functional auditory and vestibular circuits are assembled.
Cochlear and vestibular hair cells represent two related sensory systems with different functional emphasis. Cochlear structures support research on hearing, whereas vestibular structures support research on balance. Comparing their development in neonatal mice allows investigators to examine shared cellular principles while keeping auditory and vestibular circuit formation distinct.
Genetic manipulation and ototoxic stress provide controlled ways to examine how the developing inner ear responds to altered conditions or injury. Researchers can observe consequences for hair cells, supporting cells, neurons, and circuit development, then investigate repair-related responses. These perturbations connect normal developmental biology with mechanisms underlying auditory and vestibular dysfunction.
Studies can follow how sensory organs and neural connections mature during the early postnatal period. Researchers may examine hair-cell development, supporting-cell participation, neuronal connectivity, and responses to injury or repair-related conditions. This developmental window is especially useful for linking cellular changes with the formation of functional hearing and balance circuits.
A study can compare normal development with conditions involving genetic manipulation or ototoxic stress, then assess how the sensory cells and associated neural elements respond. The model supports examination of injury-related changes and repair processes within the developing inner ear. Such comparisons help identify cellular events associated with dysfunction or recovery.
The model connects sensory-organ development with neural circuit formation, making it relevant to neuroscience questions about how auditory and vestibular information enters the nervous system. Findings can clarify mechanisms associated with hearing loss and balance disorders. They may also support treatment development by identifying developmental, injury-related, or repair-related processes worth targeting.