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Immunology and Infection

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JoVE Journal Immunology and Infection
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Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Article DOI: 10.3791/51174-v • 11:32 min • February 23rd, 2014
February 23rd, 2014 •
1, 1, 1, 1, 1, 1, 1
1Department Genetics of Microorganisms, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald

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résumé
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Streptococcus pneumoniae is the leading pathogen causing severe community-acquired pneumonia and responsible for over 2 million deaths worldwide. The impact of bacterial factors implicated in fitness or virulence can be monitored in real-time in an acute mouse pneumonia or bacteremia model using bioluminescent bacteria.

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Pneumococcal Virulence Factors Acute Mouse Pneumonia Model Bioluminescent Bacteria Pneumonia Morbidity Mortality Streptococcus Pneumoniae Community-acquired Pneumonia Bacteremia Invasive Pneumococcal Disease Bacterial Fitness Pathogenicity Mechanisms Murine Models Intranasal Infection Intraperitoneal Infection Pneumococcal Dissemination Lower Respiratory Tract Blood Imaging System Analysis Software
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