Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Kirsten S. Evonuk; Carson E. Moseley; Ryan E. Doyle; Casey T. Weaver; Tara M. DeSilva

doi:10.3791/54348

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Détermination Suppression du système immunitaire contre la protection du système nerveux central pour les interventions pharmacologiques dans démyélinisation autoimmune

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Journal JoVE
Immunologie et infection

This content is Free Access.

Journal JoVE Immunologie et infection

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Détermination Suppression du système immunitaire contre la protection du système nerveux central pour les interventions pharmacologiques dans démyélinisation autoimmune

Please note that all translations are automatically generated. Click here for the English version.

12,062 Views

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09:38 min

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September 12, 2016

DOI:

10.3791/54348-v

DOI:

10.3791/54348-v

•

09:38 min

September 12, 2016

•

4 Views

Kirsten S. Evonuk*¹, Carson E. Moseley*², Ryan E. Doyle¹, Casey T. Weaver², Tara M. DeSilva^1,3,4

¹Physical Medicine and Rehabilitation,University of Alabama at Birmingham, ²Department of Pathology,University of Alabama at Birmingham, ³Department of Neurobiology,University of Alabama at Birmingham, ⁴Center for Glial Biology and Medicine,University of Alabama at Birmingham

Transcription

Summary

This protocol describes how to determine whether pharmacological treatments for experimental autoimmune encephalomyelitis show CNS protection as a consequence of suppressing immune cell infiltration or are neuroprotective during the onslaught of immune cell infiltration.