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Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells

Article DOI: 10.3791/59875-v • 07:55 min • June 21st, 2019
June 21st, 2019 •
1, 1, 1, 1, 1
1Department of Chemistry and Biochemistry, University of Oklahoma

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An integrated cell manipulation platform is developed for use in conjunction with a single-probe mass spectrometry setup for the on-line analysis of individual suspension cells under ambient conditions.

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Integrated Cell Manipulation Platform Single-probe Mass Spectrometry Analysis Drugs Metabolites Suspension Cells Native Environment Patient Derived Cell Samples Sample Preparation Cellular Heterogeneity Liquid Biopsies Disease States Glass Tubing Tapered Probe Sharp Tip Heating Coil Solenoid Plunger Orifice ICMP
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