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Developmental Biology

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JoVE Journal Developmental Biology
Durchführung von Human Skeletal Muscle Xenografts bei immundefizienten Mäusen
Dissection and Coronal Slice Preparation of Developing Mouse Pituitary Gland
Journal (Developmental Biology)
Dissection and Coronal Slice Preparation of Developing Mouse Pituitary Gland
Multi-target Chromogenic Whole-mount In Situ Hybridization for Comparing Gene Expression Domains in Drosophila Embryos
Journal (Developmental Biology)
Multi-target Chromogenic Whole-mount In Situ Hybridization for Comparing Gene Expression Domains in Drosophila Embryos
 
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Durchführung von Human Skeletal Muscle Xenografts bei immundefizienten Mäusen

Article DOI: 10.3791/59966-v • 07:48 min • September 16th, 2019
September 16th, 2019 •
1,2, 2,3, 1,2,3,4, 1,2,4
1Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, 2Department of Neurology, Johns Hopkins University School of Medicine, 3Kennedy Krieger Institute, 4Department of Neuroscience, Johns Hopkins University School of Medicine

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Komplexe menschliche Krankheiten können in traditionellen Labormodellsystemen eine Herausforderung darstellen. Hier beschreiben wir einen chirurgischen Ansatz zur Modellierung menschlicher Muskelerkrankungen durch die Transplantation menschlicher Skelettmuskelbiopsien in immundefizienten Mäusen.

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Entwicklungsbiologie Ausgabe 151 Xenograft Skelettmuskel Transplantation Modell NOD-Rag1nullIL2r ,null Mäuse immungeschwächt Myositis Muskelerkrankung
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