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A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

Article DOI: 10.3791/61865-v • 05:20 min • November 12th, 2020
November 12th, 2020 •
*1,2, *1,2,3, 1,2, 1,2, 1,2, 1,2,4, 1,2
1Laboratory of Photobiology, Keio University School of Medicine, 2Department of Ophthalmology, Keio University School of Medicine, 3Animal eye care, Tokyo Animal Eye Clinic, 4Tsubota Laboratory, Inc.
* These authors contributed equally

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Here, we describe a mouse model of retinal ischemia by transient bilateral common carotid artery occlusion using simple sutures and a clamp. This model can be useful for understanding the pathological mechanisms of retinal ischemia caused by cardiovascular abnormalities.

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Murine Model Ischemic Retinal Injury Bilateral Common Carotid Artery Occlusion Pathophysiology In Vivo Drug Screening Retinal Ischemia Vascular Diseases Diabetic Retinopathy Occlusion Of Retinal Veins Ocular Ischemic Syndrome Surgical Instruments Operation Time Deokho Lee Yukihiro Miwa BALB/c Mice Sterile Conditions Sodium Hyaluronate Eyedrop Solution Anesthesia Adhesive Tape Disinfect Sagittal Incision Salivary Glands CCA Isolation
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