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Cancer Research

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JoVE Journal Cancer Research
A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease
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A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

Article DOI: 10.3791/62033-v • 07:17 min • January 29th, 2021
January 29th, 2021 •
1,2, 3, 4, 4, 1, 5, 6, 7, 4, 2, 1,2
1Department of Neuro-Oncology, H. Lee Moffitt Cancer Center & Research Institute, 2Department of Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute, 3Department of Comparative Medicine, University of South Florida, 4Department of Breast Oncology, H. Lee Moffitt Cancer Center & Research Institute, 5Department of Cancer Physiology, H. Lee Moffitt Cancer Center & Research Institute, 6Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, 7Department of Medical Oncology, Roswell Park Comprehensive Cancer Center

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Here, we describe a murine xenograft model that functionally resembles an Ommaya reservoir in patients. We developed the Murine Ommaya to study novel therapeutics for the universally fatal leptomeningeal disease.

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Murine Ommaya Direct-targeted Therapy Leptomeningeal Disease Brain Metastases Preclinical Model Microliter Volume Cerebrospinal Fluid Blood-brain Barrier Implantation Protocol Stereotactic Surgery Aseptic Technique Training Subcutaneous Injection Sustained Release Buprenorphine Surgical Site Preparation Germicidal Skin Antiseptic
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