Hybrid Nanoparticles

Hybrid nanoparticles are nanoscale structures that combine two or more distinct materials or components to produce properties not available from a single material. Their behavior arises from the controlled organization and interaction of these components, often through chemical bonding, surface functionalization, or self-assembly during synthesis. In biology, hybrid nanoparticles can integrate features such as optical, magnetic, catalytic, or drug-carrying functions within one platform. These multifunctional systems support targeted drug delivery, molecular imaging, biosensing, and combined diagnostic and therapeutic strategies, while their size, composition, surface chemistry, and biocompatibility influence how they interact with cells and biological tissues.

Hybrid Nanoparticles - Related Videos

Research

JoVE Journal - Engineering
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Multifunctional Hybrid Fe2O3-Au Nanoparticles for Efficient Plasmonic Heating

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Cited by 16 •

2016

We describe the synthesis and properties of multifunctional Fe2O3-Au nanoparticles produced by a wet chemical approach and investigate their photothermal properties using laser irradiation. The composite Fe2O3-Au nanoparticles retain the properties of both materials, creating a multifunctional structure with excellent magnetic and plasmonic properties.

Research

JoVE Journal - Chemistry

Synthesis, Characterization, and Functionalization of Hybrid Au/CdS and Au/ZnS Core/Shell Nanoparticles

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Cited by 3 •

2016

The synthesis of uniform gold nanoparticles coated with semiconductor shells of CdS or ZnS is performed. The semiconductor coating is conducted by first depositing a silver sulfide shell and exchanging the silver cations for zinc or cadmium cations.

Harmonic Nanoparticles for Regenerative Research

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Cited by 1 •

2014

Protocol details are provided for in vitro labeling human embryonic stem cells with second harmonic generating nanoparticles. Methodologies for hESC investigation by multi-photon microscopy and their differentiation into cardiac clusters are also presented.

Education

JoVE Core - Chemistry

Hybridization of Atomic Orbitals II

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2020

sp3d and sp3d 2 Hybridization To describe the five bonding orbitals in a trigonal bipyramidal arrangement, we must use five of the valence shell atomic orbitals (the s orbital, the three p orbitals, and one of the d orbitals), which gives five sp3d hybrid orbitals. With an octahedral arrangement of six hybrid orbitals, we must use six valence shell atomic orbitals (the s orbital, the three p orbitals, and two of the d orbitals in its valence shell), which gives six sp3d 2 hybrid orbitals.

Hybridization of Atomic Orbitals I

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2020

The mathematical expression known as the wave function, ψ, contains information about each orbital and the wavelike properties of electrons in an isolated atom. When atoms are bound together in a molecule, the wave functions combine to produce new mathematical descriptions that have different shapes. This process of combining the wave functions for atomic orbitals is called hybridization and is mathematically accomplished by the linear combination of atomic orbitals. The new orbitals that...

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