Peritoneal Cytokines
Peritoneal Cytokines - Related Videos
12:58
Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
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Cited by 2 •
2017
Described here is a method for producing exogenous cytokine in patient-derived xenograft (PDX) mice via weekly intraperitoneal injection of a cytokine-transduced stromal cell line. This method broadens the utility of PDX and provides the option for transient or sustained exogenous cytokine delivery in a multitude of PDX models.
05:05
In Vivo Activation of Peritoneal Macrophages in Response to Antibodies in a Murine Model
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2025
This video demonstrates the activation of a mouse's peritoneal macrophages using intravenous immunoglobulin and bacterial lipopolysaccharide. The co-stimulation activates the peritoneal macrophages into anti-inflammatory macrophages possessing immune regulatory activity.
04:17
A Technique to Isolate Primary Mast Cells from a Murine Peritoneal Cavity
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2025
This video demonstrates a peritoneal lavage method for isolating mature connective tissue-type mast cells from the peritoneal cavity of adult mice. Upon isolating a mixture of primary immune cells from the peritoneal cavity, selective proliferation of mast cells is performed under appropriate culture conditions.
04:32
Isolation of Mouse Peritoneal Cavity Cells
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Cited by 445 •
2010
The peritoneal cavity in mammals contains different immune cell populations crucial for innate immune responses. An efficient isolation method is required for biochemical and functional analyses of these cells. Here we provide a comprehensive method for the isolation of peritoneal cavity cells in the mouse.
06:45
Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis
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Cited by 44 •
2010
The Colon Ascendens Stent Peritonitis (CASP) is a highly standardized model for polymicrobial abdominal sepsis in rodents. This article describes the surgical procedure of CASP. The CASP model and its variants allow the systematic investigation of various problems concerning the subject of sepsis.
FAQs
After binding to specific cell-surface receptors, peritoneal cytokines activate intracellular signaling pathways inside responsive cells. These pathways can change leukocyte recruitment, vascular permeability, cell growth, and tissue repair. The resulting effects coordinate communication among immune, mesothelial, and other local cells, allowing the peritoneal environment to respond to infection, injury, or inflammation.
Receptor specificity determines which cells can respond to a particular cytokine and which intracellular pathways become active. Consequently, the same peritoneal fluid environment can produce different effects in immune cells, mesothelial cells, or other local cell types. This selective communication helps explain how cytokine signals regulate distinct outcomes, including recruitment, permeability, growth, and repair.
Infection, tissue injury, and inflammation are the main conditions identified as stimuli for cytokine release in the peritoneal cavity. These triggers can alter local immune communication and produce changes in leukocyte recruitment, vascular permeability, cell growth, or tissue repair. Examining cytokine patterns therefore helps connect a measured inflammatory response with its underlying biological context.
Cytokine signaling can regulate both vascular permeability and the movement of leukocytes into the affected region. Together, these processes shape how strongly local inflammatory activity develops and how immune cells reach sites of infection or tissue damage. Measuring the associated cytokines can therefore provide biological evidence about the intensity and character of inflammation within the peritoneal cavity.
Measurements in peritoneal fluid can indicate the level of local inflammatory activity rather than describing only cellular signaling in isolation. Researchers can use these data to characterize immune responses associated with peritonitis, abdominal infection, or postoperative complications. Cytokine measurements also support comparisons of inflammatory states when studying how the peritoneal environment changes under different conditions.
They are useful when investigators need to characterize inflammation associated with peritonitis, abdominal infection, or complications after surgery. The measurements provide biomarker information about immune activity in the peritoneal cavity and can complement broader observations of disease or recovery. In biology, this makes cytokine profiles valuable for examining how local cells communicate during inflammatory responses.
Researchers can use peritoneal cytokines as biomarkers when assessing potential anti-inflammatory treatments. Changes in measured cytokine activity may indicate whether a treatment is associated with altered local immune signaling and inflammatory responses. This approach links treatment evaluation to biological outcomes in the peritoneal cavity, while also helping investigators study the mechanisms underlying inflammation and tissue repair.