Splenic Vein Ligation
Splenic Vein Ligation - Related Videos
07:29
Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure
0 Views •
Cited by 6 •
2017
Inducing rapid liver hypertrophy using Associating Liver Partition and Portal vein ligation for a Staged hepatectomy (ALPPS) has been proposed for resection of borderline resectable liver tumors. This model may elucidate mechanisms involved in rapid hypertrophy and allows testing of drugs that promote or block the acceleration of regeneration.
06:00
Laparoscopic Anatomic S7+S8d Resection Preserving Inferior Right Hepatic Vein and S6 with Right Hepatic Vein Transection
0 Views •
2025
We present a laparoscopic technique for anatomic S7+S8d resection with right hepatic vein transection, preserving the inferior right hepatic vein and segment S6. Relying on meticulous anatomical landmarks without intraoperative ultrasound, this approach offers a precise and parenchyma-sparing option for dorsally located right-liver tumors, particularly in settings with limited advanced navigation resources.
07:44
Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation
0 Views •
Cited by 19 •
2015
This protocol describes an injury model involving the surgical ligation of the pancreatic duct in the adult mouse pancreas, resulting in severe injury that establishes an environment that allows beta cell neogenesis and proliferation. This model can be used as a tool to study mechanisms involved in beta cell formation.
07:34
DNA Ligation Reactions
0 Views •
2023
In molecular biology, ligation refers to the joining of two DNA fragments through the formation of a phosphodiester bond. An enzyme known as a ligase catalyzes the ligation reaction. In the cell, ligases repair single and double strand breaks that occur during DNA replication. In the laboratory, DNA ligase is used during molecular cloning to join DNA fragments of inserts with vectors – carrier DNA molecules that will replicate target fragments in host organisms. This video provides an...
16:19
Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
0 Views •
Cited by 5 •
2014
Auxiliary liver transplantation provides a temporary support in acute hepatic failure, until regeneration of the failing liver. The heterotopic auxiliary liver transplantation (HALT) with portal vein arterialization (PVA) renders sufficient liver function. We developed an analogous technique in the rat, to examine the influence of the portal vein arterialization on the morphology and function of the graft.
FAQs
Interrupting splenic venous return changes the distribution of blood entering the portal circulation and therefore modifies portal hemodynamics throughout the abdomen. These changes can redirect venous flow toward alternative collateral pathways. In experimental models, that redistribution provides a way to examine how altered circulation affects nearby organs and processes involving the liver, pancreas, and spleen.
Collateral pathways can provide alternative routes for venous blood after the normal splenic outflow is interrupted. Their development or use changes the route taken by blood-borne cells and soluble signaling factors. This makes the technique useful for studying whether altered vascular connectivity influences the movement of cancer-related signals or cells between abdominal organs.
By changing venous circulation within the abdomen, the procedure can modify how blood-borne cells and soluble factors travel toward or away from the liver and other organs. Cancer research models can therefore use this controlled vascular alteration to investigate relationships among portal blood flow, tumor dissemination, and liver involvement without treating circulation as a fixed background condition.
Researchers can use the intervention to examine physiological responses that follow a deliberate change in abdominal venous flow. The resulting model links an identifiable surgical alteration with changes in portal hemodynamics and collateral circulation. This supports experiments focused on how vascular conditions influence disease progression and how abdominal organs respond when normal venous return is disrupted.
Its main research value lies in controlled animal models and experimental surgical studies of portal circulation, tumor dissemination, and liver involvement. Investigators can apply the model when they need to separate the effects of altered venous flow from other aspects of disease progression. It also helps evaluate vascular mechanisms relevant to upper abdominal surgical procedures.
The method provides an experimental way to study how changing venous drainage influences organs connected through abdominal circulation. Findings may clarify the vascular consequences of procedures involving the pancreas, spleen, and neighboring upper abdominal structures. In cancer research, that context is relevant when interpreting tumor spread, liver exposure, and physiological effects associated with altered portal blood flow.