Tumor Mesenchyme
Tumor Mesenchyme - Related Videos
05:06
Fluorescence-guided Tumor Resection and MSC-seeded Scaffold Implantation in Murine Model: A Surgical Procedure to Deliver Therapeutic Mesenchymal Stem Cells into Brain Tumor Resection Cavity in Mouse Model
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2025
This video presents the surgical procedure for image-guided tumor resection and implantation of a bio-scaffold seeded with genetically engineered mesenchymal stem cells or MSCs expressing tumor necrosis factor-related apoptosis-inducing ligand or TRAIL. These therapeutic MSCs have the potential in treatment of brain tumors.
11:42
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
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Cited by 7 •
2017
We present here a cell culture method for inducing mesenchymal-epithelial transitions (MET) in sarcoma cells based on combined ectopic expression of microRNA-200 family members and grainyhead-like 2 (GRHL2). This method is suitable for better understanding the biological impact of phenotypic plasticity on cancer aggressiveness and treatments.
07:23
Electroporation of Craniofacial Mesenchyme
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2011
Craniofacial cartilages develop in close contact with other tissues and are difficult to manipulate in live animals. We are using electroporation to deliver molecular tools during growth of the craniofacial skeleton while bypassing early embryonic effects. This approach will allow us to efficiently test candidate molecules in vivo.
10:37
Induction and Analysis of Epithelial to Mesenchymal Transition
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Cited by 16 •
2013
A straightforward method is described for the induction of epithelial to mesenchymal transition (EMT) in a variety of cell types. Methods for the analysis of cells in EMT states by immunocytochemistry are included.
06:02
Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition
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Cited by 16 •
2016
Here, we describe the development and application of a gel contraction assay for evaluating contractile function in mesenchymal cells that underwent epithelial-mesenchymal transition.
FAQs
Paracrine signaling creates local communication between cancer cells and stromal partners, including cancer-associated fibroblasts, endothelial cells, and immune cells. These signals can alter how the surrounding mesenchyme supports tumor growth and shapes disease behavior. Examining these interactions helps connect cellular crosstalk with processes such as invasion, angiogenesis, and treatment resistance.
Extracellular matrix remodeling changes the structure of tissue surrounding the tumor. These structural changes can influence how cells move through the tissue and how readily they access nutrients. In cancer research, examining matrix alterations therefore helps explain changes in invasion and disease progression, while also revealing how the local environment may affect therapeutic response.
Cancer-associated fibroblasts, endothelial cells, and immune cells contribute distinct cellular interactions within the tumor environment. Their communication with cancer cells can influence support for tumor growth, blood-vessel formation, immune-related behavior, and treatment response. Considering these populations together provides a broader view of how the mesenchymal compartment contributes to disease behavior than examining cancer cells alone.
Researchers can examine the stromal cells, extracellular matrix, paracrine communication, and molecular signatures associated with the tumor mesenchyme. Linking these features to invasion, metastasis, angiogenesis, or treatment resistance can clarify how the local environment influences disease. Such analyses may also identify patterns useful for prognosis or for selecting processes that warrant therapeutic investigation.
Molecular signatures can provide information about the state and behavior of the mesenchymal compartment surrounding cancer cells. When associated with disease behavior, these patterns may serve as prognostic biomarkers. They can also point to molecular processes that support the tumor, helping researchers identify potential targets for strategies aimed at disrupting tumor support.
Targeting tumor mesenchyme offers a strategy for disrupting the support that the local environment provides to cancer cells rather than focusing only on the malignant cells themselves. Because the mesenchymal compartment influences growth, invasion, angiogenesis, metastasis, and treatment resistance, its cellular interactions and molecular features may reveal complementary therapeutic opportunities.