Pta Submonomer
Pta Submonomer - Related Videos
13:42
Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
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Cited by 40 •
2011
A simple and general manual peptoid synthesis method involving basic equipment and commercially available reagents is outlined, enabling peptoids to be easily synthesized in most laboratories. The synthesis, purification and characterization of an amphiphilic peptoid 36mer is described, as well as its self-assembly into highly-ordered nanosheets.
07:09
In situ Compressive Loading and Correlative Noninvasive Imaging of the Bone-periodontal Ligament-tooth Fibrous Joint
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Cited by 17 •
2014
In this study, the use of an in situ loading device coupled with micro-X-ray computed tomography for fibrous joint biomechanics will be discussed. Experimental readouts identifiable with an overall change in joint biomechanics will include: 1) reactionary force vs. displacement, i.e. tooth displacement within the alveolar socket and its reactionary response to loading, 2) three-dimensional (3D) spatial configuration and morphometrics, i.e. geometric relationship of the tooth with the alveolar...
13:37
Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
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Cited by 5 •
2014
Peptide tertiary amides (PTAs) are a superfamily of peptidomimetics that include but are not limited to peptides, peptoids and N-methylated peptides. Here we describe a synthetic method which combines both split-and-pool and sub-monomer strategies to synthesize a one-bead one-compound library of PTAs.
12:02
An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
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Cited by 8 •
2016
A protocol to synthesize peptoids with mixed cationic functionality in the same sequence is presented (lysine- and arginine-type monomers). Subsequent testing of these compounds against Leishmania mexicana, the protozoan parasites that cause cutaneous leishmaniasis, is also described.
11:15
Nanosponge Tunability in Size and Crosslinking Density
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Cited by 1 •
2017
This article describes a process for tuning the size and crosslinking density of covalently crosslinked nanoparticles from linear polyesters containing pendant functionality. By tailoring synthesis parameters (polymer molecular weight, pendant functionality incorporation, and crosslinker equivalents), a desired nanoparticle size and crosslinking density can be achieved for drug delivery applications.
FAQs
The sequence depends on two chemically distinct events at each position. First, an activated haloacetic acid acylates the growing chain, creating a site bearing a leaving group. Next, an amine performs nucleophilic substitution, replacing that leaving group and installing the Pta-derived side chain. Repeating this sequence converts each cycle into a controlled step in oligomer composition.
Instead of synthesizing and isolating every complete monomer before assembly, the submonomer strategy builds each residue directly on the growing chain. Acylation and amine substitution are performed sequentially as needed, which makes the synthesis modular. This arrangement supports deliberate changes in sequence and composition without requiring a separately prepared full monomer for every position.
The activated haloacetic acid establishes the reactive intermediate needed for the next substitution step. Its acylation of the growing chain places a leaving group at the position where an amine will act. Consequently, this component links the chain-building stage to side-chain installation and helps preserve the stepwise control required for defined oligomer sequences.
A typical incorporation follows a two-step cycle. An activated haloacetic acid first acylates the current terminus of the growing chain. An amine is then introduced to carry out nucleophilic substitution, replacing the haloacetate leaving group and installing the desired Pta-derived side chain. Repeating this cycle extends the oligomer while controlling the identity of successive units.
Researchers can use this chemistry when they need oligomers with deliberately varied sequences and compositions. Its modular assembly is especially relevant for creating peptoid libraries, in which many related structures can be examined systematically. Such libraries support investigations of molecular recognition, biomolecular interactions, materials properties, and relationships between molecular structure and observed function.
By installing defined side chains in selected sequence positions, the method creates oligomers whose composition can be controlled during assembly. Researchers can then relate changes in sequence to differences in molecular recognition, biomolecular interactions, or materials properties. This connection makes the approach useful for examining how structural changes influence behavior across peptoids and related oligomeric systems.