S3 Gallop

An S3 gallop is a low-pitched heart sound heard early in diastole, shortly after the second heart sound, and it reflects ventricular filling during the rapid inflow phase. Clinicians detect it by auscultating with the bell of the stethoscope, typically at the cardiac apex with the patient in the left lateral decubitus position. An S3 can be normal in children, adolescents, and some young adults, but in older adults it may indicate increased ventricular volume or reduced cardiac function, including heart failure. Recognizing this finding supports bedside cardiovascular assessment, clinical reasoning, and evaluation of suspected hemodynamic abnormalities.

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Education

JoVE Science Education - Clinical Skills

Cardiac Exam III: Abnormal Heart Sounds

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2023

Source: Suneel Dhand, MD, Attending Physician, Internal Medicine, Beth Israel Deaconess Medical Center Having a fundamental understanding of normal heart sounds is the first step toward distinguishing the normal from the abnormal. Murmurs are sounds that represent turbulent and abnormal blood flow across a heart valve. They are caused either by stenosis (valve area too narrow) or regurgitation (backflow of blood across the valve) and are commonly heard as a "swishing" sound during auscultation.

Cardiac Exam II: Auscultation

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2023

Source: Suneel Dhand, MD, Attending Physician, Internal Medicine, Beth Israel Deaconess Medical Center Proficiency in the use of a stethoscope to listen to heart sounds and the ability to differentiate between normal and abnormal heart sounds are essential skills for any physician. Correct placement of the stethoscope on the chest corresponds to the sound of cardiac valves closing. The heart has two main sounds: S1 and S2. The first heart sound (S1) occurs as the mitral and tricuspid valves...

Research

JoVE Journal - Neuroscience
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Cited by 26 •

2011

Locomotion is often examined as a behavioural outcome in various models of disease in fields such as neuroscience and orthopedics. This video paper intends to describe a method for collecting ground reaction forces and kinematics from rats during unrestrained locomotion.

Protocol for Three-dimensional Confocal Morphometric Analysis of Astrocytes

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Cited by 11 •

2015

Astrocytes in the CNS change their functional and structural properties in response to harmful stimuli. This report presents a protocol for assessment of three-dimensional astrocyte morphology in diseased conditions or after therapeutic interventions.

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JoVE Journal - Biology
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Imaging of Estrogen Receptor-α in Rat Pial Arterioles using a Digital Immunofluorescent Microscope

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2011

The goal of this article is to demonstrate a method to optimize immunofluorescent detection of estrogen receptor-α (ERα) in rat pial arterial slices using a digital immunofluorescent microscope.

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