Solvate Crystals
Solvate Crystals - Related Videos
02:05
Entropy and Solvation
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2023
The process of surrounding a solute with solvent is called solvation. It involves evenly distributing the solute within the solvent. The rule of thumb for determining a solvent for a given compound is that like dissolves like. A good solvent has molecular characteristics similar to those of the compound to be dissolved. For example, polar solutions dissolve polar solutes, and apolar solvents dissolve apolar solutes. A polar solvent is a solvent that has a high dielectric constant (ϵ ≥ 15); an...
02:12
Solvating Effects
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2023
An understanding of the solvating effect helps rationalize the relation between solvation and acidity of the compound. In addition, this also explains the relative stability of conjugate bases for compounds with different pKa values. This lesson details, in-depth, the principle of solvating effects. The strength of an acid and the stability of its corresponding conjugate base are determined using pKa values. This observed relationship is a consequence of solvation, which is the interaction...
07:39
Protein Crystallization
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2023
Protein crystallization, obtaining a solid lattice of biomolecules, elucidates protein structure and enables the study of protein function. Crystallization involves drying purified protein under a combination of many factors, including pH, temperature, ionic strength, and protein concentration. Once crystals are obtained, the protein structure can be elucidated by x-ray diffraction and computation of an electron density model. This video introduces protein crystallization and shows a general...
13:38
Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
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Cited by 9 •
2017
This study presents a methodology to prepare 3D, biodegradable, foam-like cell scaffolds based on biocompatible side-chain liquid crystal elastomers (LCEs). Confocal microscopy experiments show that foam-like LCEs allow for cell attachment, proliferation, and the spontaneous alignment of C2C12s myoblasts.
12:21
Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites
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Cited by 7 •
2016
We demonstrate the preparation of siloxane-based and epoxy-based liquid crystal elastomers (LCEs) and LCE nanocomposites. The LCEs are characterized with respect to reversible strain, liquid crystal ordering, and stiffness. As a potential application, we demonstrate their use as shape-responsive substrates in a custom device for active cell culture.
FAQs
Solvent molecules occupy defined sites within the crystal lattice and interact with nearby compound molecules, including through hydrogen bonding. These interactions can affect how the surrounding molecules are arranged and how strongly the lattice is maintained. As a result, the incorporated solvent is a structural feature that may influence the solid form’s behavior during development and storage.
Solvent composition, temperature, and drying conditions are important variables. Changes in solvent composition can alter which crystalline form develops, while temperature may influence formation or transformation. Drying can also change the amount of solvent retained in the lattice. Controlling these conditions helps reduce unintended changes in the solid form during processing.
The amount and organization of incorporated solvent can influence solid-state stability, dissolution, and bioavailability. It may also affect how consistently a drug substance behaves during manufacturing. Because these properties are linked to clinical product performance, researchers evaluate solvent-containing forms rather than treating solvent content as an incidental feature of crystallization.
Processing and storage may alter the solvent content within the lattice, potentially causing a crystal form to transform. Such changes can affect stability, dissolution, and manufacturing consistency. Evaluating the material under relevant drying, processing, and storage conditions helps researchers determine whether the selected form remains reliable throughout the drug-substance lifecycle.
Characterization should determine how the incorporated solvent relates to the crystal form and whether that form remains stable under intended conditions. Researchers also assess consequences for dissolution, bioavailability, and manufacturability. These evaluations support comparison of candidate solid forms and help identify a drug substance that can maintain consistent performance.
They become especially important when crystallization, drying, processing, or storage may change incorporated solvent content. Researchers use this information to judge solid-state stability and manufacturing reliability alongside dissolution and bioavailability. The goal is to select a form whose properties remain sufficiently consistent for clinical development and controlled pharmaceutical production.