Urethral Strictures
Urethral Strictures - Related Videos
05:09
Urethral Stricture Induction Followed by Buccal Mucosa Graft Urethroplasty in a Rat Model
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Cited by 3 •
2023
In the present protocol, a urethral stricture induction was developed in Wistar rats, followed by urethral reconstruction with a buccal mucosa graft. A retrograde urethrogram and laser Doppler assessment were performed, validating urethral reconstruction (after stricture formation) and graft placement.
03:55
Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis
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Cited by 1 •
2024
This article introduces a surgical method using a pedicled tunica vaginalis to treat long-segment urethral stricture resulting from lichen sclerosus. The tunica vaginalis is an excellent substitute for the urethra, leading to quick postoperative recovery for patients.
05:57
ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
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Cited by 14 •
2017
This study reports a successful method of endoscopical adipose tissue-derived stromal cell (ADSC)-sheet transplantation for esophageal stricture prevention after an extended endoscopic submucosal dissection (ESD) in a swine model.
01:30
Esophageal Strictures-I: Introduction
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2025
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous). Etiology The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
07:42
Nerve-sparing Mid-urethral Obstruction (NeMO) in Female Small Rodents
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Cited by 7 •
2017
Traditional modeling of partial bladder outlet obstruction in rodents is fraught with animal mortality. A denervation injury from dissection around the proximal urethra and bladder neck is also of major concern. We developed and evaluated a safe and reliable mid-urethral obstruction model, avoiding the shortcomings of the traditional model.
FAQs
After injury, inflammation, infection, or instrumentation damages the urethral lining, the healing response can produce fibrosis, or scar tissue formation. As this tissue accumulates, the urethral channel becomes narrower and offers greater resistance to urine flow. This mechanism explains why an initially local injury can develop into a clinically significant obstruction affecting urinary health.
Location and length indicate how much of the urethra is affected and help clinicians characterize the narrowing. Recurrence adds another important dimension because a previously treated stricture may narrow again. Together, these features guide treatment selection, allowing clinicians to match dilation, internal urethrotomy, or urethroplasty to the individual clinical situation.
Dilation, internal urethrotomy, and urethroplasty represent different treatment approaches for restoring the urethral passage. The overview supports choosing among them according to stricture location, length, and recurrence rather than applying one option universally. This individualized selection is important because the treatment decision influences the goal of improving urination and reducing further recurrence.
Fibrosis is the structural change that converts damage to the urethral lining into a persistent narrowing. Instead of remaining a temporary response to injury, scar formation reduces the channel diameter and increases resistance to urine flow. Recognizing this process helps explain why identifying the original cause, such as instrumentation or inflammation, is relevant during clinical evaluation.
Evaluation combines the patient’s medical history with tests that assess urinary function and visualize the urethra. Uroflowmetry contributes flow information, while retrograde urethrography and cystoscopy provide imaging or direct examination of the narrowed area. Using these findings together helps clinicians determine the stricture’s location and length before selecting an appropriate treatment.
Retrograde urethrography and cystoscopy help clinicians examine the urethra more directly than history alone. These studies support identification and characterization of the narrowed segment, while the broader assessment incorporates location and length into treatment planning. Their findings are therefore relevant to deciding whether dilation, internal urethrotomy, or urethroplasty is most suitable.
Uroflowmetry is part of the clinical evaluation for suspected urethral strictures and adds a functional perspective to the assessment. Because narrowing can restrict the passage of urine, flow testing helps document how urination is affected. Clinicians interpret it alongside medical history, imaging, and cystoscopy rather than relying on a single test to establish the treatment plan.
Accurate diagnosis connects the underlying narrowing with its extent and clinical consequences, giving clinicians a basis for selecting treatment. A well-directed assessment can support restoration of urination, help prevent complications, and contribute to reducing recurrence. This makes diagnostic testing an active part of management rather than merely a step performed before treatment.