Perivascular Stem Cells
Perivascular Stem Cells - Related Videos
07:05
Use of Human Perivascular Stem Cells for Bone Regeneration
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Cited by 42 •
2012
Human perivascular stem cells (PSCs) are a novel stem cell class for skeletal tissue regeneration similar to mesenchymal stem cells (MSCs). PSCs can be isolated by FACS (fluorescence activated cell sorting) from adipose tissue procured during standard liposuction procedures, then combined with an osteoinductive scaffold to achieve bone formation in vivo.
08:15
Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
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Cited by 7 •
2016
Human cardiac tissue harbours multipotent perivascular precursor cell populations that may be suitable for myocardial regeneration. The technique described here allows for the simultaneous isolation and purification of two multipotent stromal cell populations associated with native blood vessels, i.e. CD146+CD34- pericytes and CD34+CD146- adventitial cells, from the human myocardium.
09:05
A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells
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Cited by 4 •
2017
Here we present a novel clinical grade isolation and culture method for kidney Perivascular Stromal Cells (kPSCs) based on whole organ perfusion with digestive enzymes and NG2-cell enrichment. With this method, it is possible to acquire sufficient cell numbers for cellular therapy.
22:06
Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
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Cited by 7 •
2007
This protocol details the derivation of transplantable hematopoietic stem cells from mouse embryonic stem cells (ESC) and their subsequent injection into lethally irradiated recipient mice. Briefly, ESC are differentiated as embryoid bodies, which are then infected with retroviral HoxB4 and co-cultured with OP9 stromal cells and hematopoietic cytokines.
20:38
Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)
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Cited by 31 •
2007
FAQs
Endothelial cells form an important cellular partner within the vascular niche. Their interactions with perivascular stem cells help regulate self-renewal, migration, and differentiation rather than treating these activities as independent processes. In developmental biology, examining this relationship helps explain how vascular structures communicate with nearby progenitor populations and contribute to tissue organization during growth.
Local signaling cues provide environmental information that can influence whether perivascular stem cells remain as a progenitor population, migrate, or differentiate. This regulation connects the immediate vascular environment with changes in surrounding tissues. Understanding these signals is therefore important for explaining how developmental niches maintain cells while also directing lineage-specific contributions to tissue formation and repair.
Research on Perivascular Stem Cells helps clarify how blood vessels coordinate with neighboring tissues during development. It also addresses how progenitor populations are maintained and how vascular environments influence cell fate. These questions connect vessel formation with broader tissue organization, offering a framework for understanding why vascular niches can affect the development of multiple surrounding cell types.
Their multipotency allows perivascular stem cells to contribute to more than one tissue lineage, including bone, cartilage, and smooth muscle. The relevant outcome depends on local regulation within the vascular niche. Studying this flexibility helps developmental biologists link environmental signals with the emergence of distinct tissue types and with the organization of tissues around blood vessels.
A useful investigation considers the cells together with their vascular environment, especially interactions with endothelial cells and the signaling cues present locally. Researchers can then relate those conditions to self-renewal, migration, differentiation, and tissue organization. This integrated perspective is more informative than examining progenitor behavior without considering the surrounding blood vessel context.
Their ability to participate in tissue organization and to differentiate toward bone, cartilage, and smooth muscle lineages makes them relevant to tissue repair and regenerative medicine research. Studies can also use them to examine how vascular environments support regeneration. The same biological relationships are valuable for disease modeling and for investigating vascular development in developmental biology.