Central Corneal Thickness
Central Corneal Thickness - Related Videos
08:37
Corneal Donor Tissue Preparation for Endothelial Keratoplasty
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Cited by 31 •
2012
Endothelial corneal transplantation is a surgical technique for treatment of posterior corneal diseases. Mechanical microkeratome dissection to prepare tissue results in thinner, more symmetric grafts with less endothelial cell loss and improved outcomes. Dissections can be performed at the eye bank prior to corneal transplantation surgery.
04:11
Laser-assisted Selective Ablation of Porcine Corneal Endothelial Cells: A Technique to Induce Focused Porcine Corneal Endothelial Injury for Ex Vivo Studies
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2025
This video demonstrates a non-invasive laser-assisted procedure to selectively damage the corneal endothelial cells in the porcine eye. The developed ex vivo model of endothelial cell damage can be used to study diseases of the corneal endothelium.
07:29
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
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Cited by 30 •
2015
Corneal collagen cross-linking (CXL) is the only conservative treatment currently available to halt keratoconus progression by improving the biomechanical rigidity of the corneal stroma. The aim of this manuscript is to highlight the methods of three different protocols of CXL: conventional CXL (C-CXL), accelerated CXL (A-CXL), and iontophoresis CXL (I-CXL).
10:52
An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse
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Cited by 75 •
2014
Neovascularization (NV) of the cornea can complicate multiple visual pathologies. Utilizing a controlled, alkali-burn injury model, a quantifiable level of corneal NV can be produced for mechanistic study of corneal NV and evaluation of potential therapies for neovascular disorders.
09:05
In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition
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Cited by 7 •
2016
A primary culture of bovine corneal endothelial cells was used to investigate the mechanism of corneal endothelial-mesenchymal transition. Furthermore, a rat corneal endothelium cryoinjury model was used to demonstrate corneal endothelial-mesenchymal transition in vivo.
FAQs
Corneal thickness is not merely a structural measurement; its biomechanics can influence tonometry readings, so the same measured intraocular pressure may require different clinical interpretation depending on the corneal measurement. Incorporating this variable helps clinicians assess glaucoma-related risk more appropriately rather than treating a tonometry value as independent of corneal properties.
Repeated measurements can show whether corneal structure remains stable or changes during follow-up. In this context, thickness is used as a longitudinal indicator rather than an isolated number. Comparing results over time may help clinicians evaluate structural stability and assess whether treatment outcomes are consistent with the observed clinical course.
Thickness measurements provide one structural data point when clinicians evaluate disorders such as keratoconus or edema. Their value lies in adding objective information about the cornea to the clinical assessment. When measurements are repeated, changes can also help indicate whether the cornea is remaining stable or changing during observation or treatment.
Clinicians use pachymetry to quantify the distance between the corneal epithelium and endothelium at the optical center. The measurement may be obtained with ultrasound or optical imaging, so the procedure is not limited to one technology. The resulting value can then be incorporated into ophthalmic assessment, including interpretation of intraocular pressure and preoperative review.
Before refractive surgery, clinicians include central corneal thickness in preoperative screening because it supplies information about corneal structure. Its role is to add corneal structural information to the screening process, helping clinicians evaluate the cornea before surgery. This makes the measurement relevant to assessment of a refractive procedure as well as to other ophthalmic decisions.
Tracking central corneal thickness over time allows clinicians to compare current findings with earlier measurements. That longitudinal view can help assess structural stability and monitor treatment outcomes, rather than relying on a single observation. Serial data are particularly useful when the clinical question concerns whether the cornea is changing during follow-up or responding to management.