High-frequency Electric Knife

A high-frequency electric knife is an electrosurgical instrument that uses high-frequency electrical energy to cut tissue and control bleeding during medical procedures. Its active electrode delivers alternating current through tissue, where electrical resistance converts the energy into localized heat; depending on the waveform, power, and contact conditions, this heat can vaporize tissue for cutting or denature proteins to achieve coagulation. Commonly used in open and minimally invasive surgery, the device supports precise dissection, hemostasis, and reduced reliance on conventional blades. Understanding its energy delivery and tissue effects is essential for selecting appropriate settings, limiting unintended thermal injury, and improving surgical safety.

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Research

JoVE Journal - Bioengineering
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Specimen Preparation, Imaging, and Analysis Protocols for Knife-edge Scanning Microscopy

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Cited by 15 •

2011

The full process from brain specimen preparation to serial sectioning imaging using the Knife-Edge Scanning Microscope, to data visualization and analysis is described. This technique is currently used to acquire mouse brain data, but it is applicable to other organs, other species.

Research

JoVE Journal - Bioengineering

Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions

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Cited by 7 •

2013

We describe the device fabrication and measurement protocol for carbon nanotube based high frequency biosensors. The high frequency sensing technique mitigates the fundamental ionic (Debye) screening effect and allows nanotube biosensor to be operated in high ionic strength solutions where conventional electronic biosensors fail. Our technology provides a unique platform for point-of-care (POC) electronic biosensors operating in physiologically relevant conditions.

Education

JoVE Science Education - Physics
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Electric Potential

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2023

Source: Yong P. Chen, PhD, Department of Physics & Astronomy, College of Science, Purdue University, West Lafayette, IN Electric potential, also known as "voltage", measures the electric potential energy per unit charge. Electric field is a scalar quantity and is fundamental to many electrical effects. Like potential energy, what is physically meaningful is the difference in the electric potential. For example, the spatial variation in the electric potential is related to the electric...

Characterizing Far-infrared Laser Emissions and the Measurement of Their Frequencies

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Cited by 4 •

2015

We describe the generation of far-infrared radiation using an optically pumped molecular laser along with the measurement of their frequencies with heterodyne techniques. The experimental system and techniques are demonstrated using difluoromethane (CH2F2) as the laser medium whose results include three new laser emissions and eight measured laser frequencies.

Electrical Safety

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2023

Robert M. Rioux & Suprita Jharimune, Pennsylvania State University, University Park, PA Among the many hazards present in the laboratory, electrical hazards are one of the most common we must be cognizant of since most of the laboratory equipment we use requires electricity for operation. Improper handling or operation of electrical devices might lead to electric shock with the potential risk of injury or even death. Electric sparks can lead to fire or explosion (since many flammable...

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