Thrombus Morphology
Thrombus Morphology - Related Videos
09:01
Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse
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Cited by 4 •
2017
The ear model of the hairless SKH1-Hrhr mouse enables intravital fluorescence microscopy of microcirculation and phototoxic thrombus induction without prior surgical preparation in the examined microvascular bed. Therefore, the ear of the hairless mouse is an excellent in vivo model to study the complex interactions during microvascular thrombus formation, thrombus evolution, and thrombolysis.
05:54
Intravital Fluorescence Microscopy to Study Microvascular Thrombus Formation
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2025
This video demonstrates the intravital fluorescence microscopy technique to study thrombus formation in a mouse model. The mouse is injected with a fluorophore-labeled polysaccharide to monitor blood circulation. Upon illumination with a high-intensity light, the phototoxic induction of an injury in the microvasculature of the ear leads to the formation of a thrombus, which is confirmed by visualizing the obstruction in the blood flow.
08:50
Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
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2026
This work describes a microfluidic assay that uses shear stress to trigger thrombus formation in blood and characterizes the thrombus by multiple dimensions of readout. The assay can measure the prothrombotic tendency of blood samples, and is thus useful in disease diagnosis, drug discovery, as well as basic mechanistic studies related to thrombosis.
02:05
Visualization of a Cerebral Thrombus in a Mouse Using Micro-Computed Tomography Imaging
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2025
Source: Kim, D., et. al. Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli. J. Vis. Exp. (2016)This video demonstrates visualization of cerebral thrombus in mice using micro-computed tomography (micro-CT) imaging. A cerebral thrombus mouse model is injected with fibrin-targeted gold nanoparticles acting as a contrasting agent. The mouse is placed on the bed of a micro-CT machine, and images are acquired from multiple angles.
11:18
Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
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Cited by 29 •
2013
Here we report an experimental technique of fluorescence intravital microscopy to visualize heterotypic platelet-neutrophil interactions on the activated endothelium during vascular inflammation and thrombus formation in live mice. This microscopic technology will be valuable to study the molecular mechanism of vascular disease and to test pharmacologic agents under pathophysiological conditions.
FAQs
These processes contribute different structural features to a developing thrombus. Platelet activation and coagulation support fibrin deposition, while local blood-flow conditions influence where material accumulates and how the clot is arranged. Examining their combined effects helps connect a thrombus’s architecture with the biological circumstances that produced it, rather than interpreting structure in isolation.
A thrombus can change substantially after its initial formation. Continued deposition may enlarge it, contraction can alter its internal architecture, and organization can produce more established structural patterns. Recanalization, meaning the development of channels through the clot, further changes its appearance. These processes help investigators estimate developmental stage and interpret whether the thrombus remains structurally stable.
Location and structural appearance provide complementary clues when distinguishing arterial from venous thrombosis. Morphology should therefore be interpreted alongside the anatomic setting and the method used to visualize the clot. This combined assessment can clarify the type of thrombosis under consideration and support evaluation of its potential clinical effects, including implications for stability and embolic risk.
Assessment can use pathology, angiography, ultrasound, computed tomography, or magnetic resonance imaging. These approaches provide different ways to examine clot structure, location, and developmental features, although the overview does not assign a single modality to every situation. Together, they support characterization of thrombi in patients and provide measurements or observations for thrombosis research.
These methods can help characterize where a thrombus is located, how it is structured, and which stage of development it may represent. Such information supports estimates of clot age and stability rather than relying only on the presence of an obstruction. The resulting assessment can help clinicians interpret possible effects and consider treatment decisions.
Morphologic assessment can inform decisions involving antiplatelet or anticoagulant therapy by linking clot appearance with developmental stage, stability, and possible embolic risk. In research, these features help investigators examine thrombosis mechanisms and study responses to treatment. Comparing morphology before or after therapy can therefore connect structural changes with the biological behavior of the thrombus.