Perivascular Spaces
Perivascular Spaces - Related Videos
01:23
Magnetic Resonance Imaging of Perivascular Spaces in the Human Brain During a Small Vessel Stroke
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2025
Perivascular spaces (PVS) are fluid-filled spaces around the brain blood vessels involved in fluid drainage.To examine alterations in PVS during a small vessel stroke, perform magnetic resonance imaging (MRI) of the basal ganglia region in the patient’s brain.The imaging protocol includes the T2-weighted fast spin echo and fluid-attenuated inversion recovery (FLAIR) sequences.T2-weighted imaging enhances the contrast between cerebrospinal fluid (CSF)-filled PVS and surrounding tissue.FLAIR...
07:05
Use of Human Perivascular Stem Cells for Bone Regeneration
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Cited by 42 •
2012
Human perivascular stem cells (PSCs) are a novel stem cell class for skeletal tissue regeneration similar to mesenchymal stem cells (MSCs). PSCs can be isolated by FACS (fluorescence activated cell sorting) from adipose tissue procured during standard liposuction procedures, then combined with an osteoinductive scaffold to achieve bone formation in vivo.
09:05
A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells
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Cited by 4 •
2017
Here we present a novel clinical grade isolation and culture method for kidney Perivascular Stromal Cells (kPSCs) based on whole organ perfusion with digestive enzymes and NG2-cell enrichment. With this method, it is possible to acquire sufficient cell numbers for cellular therapy.
08:15
Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
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Cited by 7 •
2016
Human cardiac tissue harbours multipotent perivascular precursor cell populations that may be suitable for myocardial regeneration. The technique described here allows for the simultaneous isolation and purification of two multipotent stromal cell populations associated with native blood vessels, i.e. CD146+CD34- pericytes and CD34+CD146- adventitial cells, from the human myocardium.
07:54
In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen
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Cited by 16 •
2012
Simple and reproducible procedures are described for making three structurally distinct collagen assemblies from a common commercially available Type I collagen monomer. Native type, fibrous long spacing or segmental long spacing collagen can be constructed by varying the conditions to which the 300 nm long and 1.4 nm diameter monomer building block is exposed.
FAQs
Fluid movement through perivascular spaces can connect processes occurring near penetrating vessels with the surrounding brain extracellular environment. Because cerebrospinal fluid and solutes can move through this compartment, researchers use it to study how substances are distributed through tissue and how waste-clearance pathways operate. This makes the spaces relevant to glymphatic function.
The connection provides a structural setting for communication between vascular and neural systems. Studying it helps researchers relate vascular conditions to changes in the surrounding brain tissue, including processes involving fluid exchange and clearance. This perspective supports investigations of neurovascular health rather than treating blood vessels and neural environments as separate systems.
Changes such as enlargement can provide information about brain structure, aging, and small-vessel pathology. They do not represent a single conclusion by themselves; instead, researchers interpret them as structural findings within broader studies of vascular injury, fluid movement, and clearance. Their value lies in connecting visible anatomy with possible changes in brain physiology.
Magnetic resonance imaging can visualize perivascular spaces within the brain, with enlarged spaces being particularly observable. Researchers use the resulting structural information to examine patterns associated with aging and small-vessel pathology. Imaging therefore offers a noninvasive way to investigate these compartments in relation to brain anatomy and neurovascular status.
These studies can address how brain fluids and solutes move, how waste-clearance processes function, and how vascular conditions relate to neural tissue. They also help researchers examine glymphatic function, neurovascular health, aging, and small-vessel pathology. Combining anatomical observations with fluid-dynamics research can clarify relationships between structure and clearance.
Their location and fluid-related role make them useful for examining how vascular injury may affect movement through brain tissue and waste clearance. Researchers can investigate whether structural changes, including enlargement, occur alongside these concerns. This provides a neuroscience context for linking vascular pathology with altered fluid handling and broader brain health.