Cadaveric Femora

Cadaveric femora are human thigh bones obtained after death and preserved for anatomical study, providing bioengineers with realistic models of skeletal structure and material behavior. Researchers characterize their geometry and tissue properties using imaging, dissection, and controlled mechanical loading, which can reveal how bone responds to compression, bending, and fracture. These specimens support the evaluation of orthopedic implants, fixation devices, fracture mechanics, and surgical techniques under biologically relevant conditions. Findings from cadaveric femora also help validate computational models and inform the design of safer, more effective treatments for musculoskeletal injuries and disease.

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JoVE EoE - Large Animal Models

Harvesting Articular Cartilage From Joints of an Equine Donor: A Surgical Procedure to Isolate Vascular Connective Tissue From Cadaveric Joints of an Equine Donor

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2025

In this video, we demonstrate the extraction of articular cartilage from an equine cadaveric joint. The isolated articular cartilage can be used for further downstream analysis.

Creating a Box-Cavity Defect Model in the Cortical Bone of Rat Femora

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Cited by 1 •

2023

Here, we present a protocol for creating a box-cavity defect in rat femoral diaphysis tissue. This model can assess biomaterial performance under biomechanical stress and explore mechanisms of bone regeneration related to intramembranous osteogenesis.

Extracting the Cochlea from a Human Temporal Bone: A Cadaveric Protocol

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2023

This article presents a reliable method for extracting the human cochlea from the cadaver temporal bone by drill-out while following distinct anatomical landmarks.

Simulating Fall-Induced Wrist Fractures Using a Cadaveric Human Forearm Specimen

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2026

Source:Anthony J. Yosick1,2, Christine Massie1, Emma Knapp2, Hani A. Awad1,2,31Department of Biomedical Engineering, University of Rochester, US2Center for Musculoskeletal Research, Department of Orthopedics, University of Rochester Medical Center, USA3Department of Orthopedics, University of Rochester Medical Center, USAThe video demonstrates fall-related wrist fractures using human cadaver forearms with varying bone densities. Specimens are standardized by removing upper soft tissue,...

A Method to Estimate Cadaveric Femur Cortical Strains During Fracture Testing Using Digital Image Correlation

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Cited by 5 •

2017

In this protocol, the femur surface strains are estimated during fracture testing using the digital image correlation technique. The novelty of the method involves application of a high-contrast stochastic speckle pattern on the femur surface, carefully specified illumination, high speed video capture, and digital image correlation analysis for strain calculations.

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