Sensory Neuropathy
Sensory Neuropathy - Related Videos
13:11
Sensory Exam
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2023
Source:Tracey A. Milligan, MD; Tamara B. Kaplan, MD; Neurology, Brigham and Women's/Massachusetts General Hospital, Boston, Massachusetts, USA A complete sensory examination consists of testing primary sensory modalities as well as cortical sensory function. Primary sensory modalities include pain, temperature, light touch, vibration, and joint position sense. Sensation of the face is discussed in the videos Cranial Nerves Exam I and II, as are the special senses of smell, vision, taste, and...
02:26
Establishing a Mouse Model of Small Fiber Neuropathy Using Resiniferatoxin
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2025
This video demonstrates a method for establishing a small fiber neuropathy model in mice using the TRPV1 agonist resiniferatoxin (RTX). It outlines the steps involved in administering RTX to mice and explains how RTX induces neuronal death in small-diameter sensory neurons, thereby establishing the neuropathy model.
08:56
Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
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Cited by 4 •
2021
This article presents a protocol for nerve ultrasound in polyneuropathies to aid the diagnosis of inflammatory neuropathies.
01:31
What is a Sensory System?
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2019
Sensory systems detect stimuli—such as light and sound waves—and transduce them into neural signals that can be interpreted by the nervous system. In addition to external stimuli detected by the senses, some sensory systems detect internal stimuli—such as the proprioceptors in muscles and tendons that send feedback about limb position. Sensory systems include the visual, auditory, gustatory (taste), olfactory (smell), somatosensory (touch, pain, temperature, and proprioception), and vestibular...
01:22
Diabetic Neuropathy
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2026
DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
FAQs
The consequences depend on whether injury primarily affects axons, the long extensions that carry nerve impulses, or myelin, the sheath that supports electrical conduction. Axonal damage can reduce the signal reaching the nervous system, whereas myelin disruption can alter how efficiently signals travel. Linking these structural changes to sensory loss helps explain variation in neuropathy symptoms.
Sensory nerves carry information from several types of receptors in the skin, muscles, and joints. Damage can disrupt the transmission of signals from these different locations, so temperature perception, touch, or awareness of body position may become impaired to different degrees. Studying these changes helps biologists connect the affected sensory pathway with its normal function.
These conditions represent different contexts in which sensory nerve structure or function can become impaired. Diabetes, toxic exposure, and inherited disorders may affect peripheral nerve axons or their myelin sheaths, altering signal transmission. Comparing these causes helps researchers investigate why nerve damage develops and identify patterns that may guide diagnosis, prevention, or treatment research.
A study can begin by relating changes in sensation to the structure and function of peripheral nerves. Researchers then examine how altered axons or myelin affect signal transmission, consider possible causes, and evaluate diagnostic approaches. Treatment studies can extend this work by testing whether interventions improve sensory function or limit further nerve damage.
Diagnostic approaches help connect reported sensory changes with disruptions in nerve structure or signal transmission. They can support investigation of symptoms such as numbness, tingling, burning pain, or reduced temperature and touch perception, while also helping researchers consider potential causes. This information is valuable for evaluating disease mechanisms and assessing the effects of treatment.
Sensory neuropathy provides a model for examining how peripheral nerve injury changes sensation and how those changes relate to axons and myelin. Research can use this relationship to investigate causes, evaluate treatments, and explore ways to prevent additional damage. It also supports efforts to restore sensory function by linking biological changes with measurable sensory outcomes.