Beta Carbon

Beta carbon is the carbon atom located two positions from a reference functional group or reaction center, typically separated from it by an alpha carbon, and this designation helps describe molecular structure and reactivity. In organic reactions, a beta carbon often bears a beta hydrogen that can be removed together with a leaving group on the neighboring alpha carbon; this concerted or stepwise beta-elimination process forms a carbon–carbon double bond. Identifying beta carbons supports systematic nomenclature and helps predict elimination products, alkene formation, stereochemical outcomes, and reaction mechanisms in organic and biological chemistry.

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Research

JoVE EoE - Immunotherapy

An Assay for Analyzing Test β-Glucan as an Immunotherapy Strategy against Brain Cancer Cells

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2025

This video demonstrates an in vitro assay utilizing β-glucans to activate microglial cells for the production of superoxide radicals, a reactive oxygen species. In brain cancer cells, the generated reactive oxidants actively suppress tumor cell proliferation and induce cell death.

Education

JoVE Business - Finance

Beta

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2024

Beta is a crucial metric in finance used to assess an investment's risk and expected return relative to the overall market. It is calculated as the slope of the line in a scatterplot that compares the returns of an individual stock to the returns of the market benchmark, typically represented by a broad market index. Beta quantifies how much a stock's price moves in response to market movements, providing insight into its volatility and systematic risk. A beta of one indicates that the stock's...

The Carbon Cycle

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2019

Carbon is the basis of all organic matter on Earth, and is recycled through the ecosystem in two primary processes: one in which carbon is exchanged among living organisms, and one in which carbon is cycled over long periods of time through fossilized organic remains, weathering of rocks, and volcanic activity. Human activities, including increased agricultural practices and the burning of fossil fuels, has greatly affected the balance of the natural carbon cycle. Biological Carbon Cycle All...

In situ Quantification of Pancreatic Beta-cell Mass in Mice

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Cited by 6 •

2010

The following protocol outlines the process of pancreatic dissection for virtual slice imaging, and the subsequent quantification of all GFP-tagged beta-cells in the entire pancreas.

A Tailored HPLC Purification Protocol That Yields High-purity Amyloid Beta 42 and Amyloid Beta 40 Peptides, Capable of Oligomer Formation

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Cited by 6 •

2017

Herein we report a tailored HPLC purification protocol that yields high-purity amyloid beta 42 (Aβ42) and amyloid beta 40 (Aβ40) peptides, capable of oligomer formation. Amyloid beta is a highly aggregation prone, hydrophobic peptide implicated in Alzheimer's disease. The amyloidogenic nature of the peptide makes its purification a challenge.

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