Ionizable Protons

Ionizable protons are hydrogen nuclei that can be transferred from a molecule during an acid–base reaction, giving the molecule a pH-dependent charge. Their ionization depends on the chemical environment, including neighboring electronegative atoms, resonance stabilization, solvent, and pH, and is commonly described by the acid dissociation constant, pKa. Identifying ionizable protons helps chemists predict molecular structure, reactivity, solubility, and behavior during titration and buffer formation. In biological and pharmaceutical chemistry, protonation state influences how compounds cross membranes, bind to biomolecules, and respond to changing physiological conditions, making this concept essential for understanding acids, bases, and molecular interactions.

Ionizable Protons - Related Videos

Education

JoVE Core - Chemistry

Ionization Energy

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2020

The amount of energy required to remove the most loosely bound electron from a gaseous atom in its ground state is called its first ionization energy (IE1). The first ionization energy for an element, X, is the energy required to form a cation with 1+ charge: The energy required to remove the second most loosely bound electron is called the second ionization energy (IE2). The energy required to remove the third electron is the third ionization energy, and so on. Energy is always required...

Proton Exchange Membrane Fuel Cells

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2023

Source: Laboratories of Margaret Workman and Kimberly Frye - Depaul University The United States consumes a large amount of energy – the current rate is around 97.5 quadrillion BTUs annually. The vast majority (90%) of this energy comes from non-renewable fuel sources. This energy is used for electricity (39%), transportation (28%), industry (22%), and residential/commercial use (11%). As the world has a limited supply of these non-renewable sources, the United States (among others) is...

Research

JoVE Journal - Chemistry

A Study of the Complexation of Mercury(II) with Dicysteinyl Tetrapeptides by Electrospray Ionization Mass Spectrometry

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2016

The characterization of complexes formed in different relative ratios of mercury(II) to dicysteinyl tetrapeptides by electrospray ionization orbitrap mass spectrometry is presented.

Imaging of Biological Tissues by Desorption Electrospray Ionization Mass Spectrometry

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Cited by 21 •

2013

Desorption electrospray ionization mass spectrometry (DESI-MS) is an ambient method by which samples, including biological tissues, can be imaged with minimal sample preparation. By rastering the sample below the ionization probe, this spray-based technique provides sufficient spatial resolution to discern molecular features of interest within tissue sections.

Research

JoVE Journal - Engineering
Free Sample

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

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Cited by 2 •

2014

A growing number of radiation therapy devices offer the advantage of delivering the dose through very small beams to the tumor, allowing for increased conformity and higher doses per fraction. Many different detectors can be used for the dosimetry of these small fields. In the present study, the effect of ion recombination is investigated for a liquid ionization chamber using a stereotactic radiation therapy system.

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