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JoVE Journal
Bioengineering

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Imaging of Biological Tissues by Desorption Electrospray Ionization Mass Spectrometry
 

Imaging of Biological Tissues by Desorption Electrospray Ionization Mass Spectrometry

Article DOI: 10.3791/50575
July 12th, 2013

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Summary July 12th, 2013

Desorption electrospray ionization mass spectrometry (DESI-MS) is an ambient method by which samples, including biological tissues, can be imaged with minimal sample preparation. By rastering the sample below the ionization probe, this spray-based technique provides sufficient spatial resolution to discern molecular features of interest within tissue sections.

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