Recrystallization Inhibition
Recrystallization Inhibition - Related Videos
03:12
Recrystallization - Concepts
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2020
Recrystallization Often, the desired product of a chemical reaction is part of a more complex reaction mixture, which can be composed of the solvent, starting materials, and impurities. Learning how to purify organic compounds properly is a valuable technique in organic chemistry. Recrystallization harnesses the differences in solubility of the desired compound and the impurity in the solvent to purify the desired product as a solid. There are three standard methods of purification:...
13:15
Recrystallization - Student Protocol
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2020
Source: Lara Al Hariri and Ahmed Basabrain at the University of Massachusetts Amherst, MA, USA Recrystallization of AcetanilideExpand In this part of the lab, you'll purify acetanilide by recrystallization from an aqueous solution. Acetanilide is moderately soluble in boiling water, but it's much less soluble in room temperature and cold water. Aniline, a potential impurity, is much more soluble in room temperature water. Thus, you'll first make a saturated solution of acetanilide in boiling...
03:03
Recrystallization - Instructor Prep
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2020
Source: Lara Al Hariri at the University of Massachusetts Amherst, MA, USA Preparation of the LaboratoryExpand Here, we show the laboratory preparation for 10 students working in pairs, with some excess. Please adjust quantities as needed. To set up for this lab experiment, wear the appropriate personal protective equipment, including a lab coat, chemical splash goggles, and gloves. Confirm that the lab has a glass waste container and a container for solid acetanilide and...
09:58
Purifying Compounds by Recrystallization
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2023
Source: Laboratory of Dr. Jimmy Franco - Merrimack College Recrystallization is a technique used to purify solid compounds.1 Solids tend to be more soluble in hot liquids than in cold liquids. During recrystallization, an impure solid compound is dissolved in a hot liquid until the solution is saturated, and then the liquid is allowed to cool.2 The compound should then form relatively pure crystals. Ideally, any impurities that are present will remain in the solution and will not be...
09:43
Identification of Plant Ice-binding Proteins Through Assessment of Ice-recrystallization Inhibition and Isolation Using Ice-affinity Purification
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Cited by 5 •
2017
This paper outlines the identification of ice-binding proteins from freeze-tolerant plants through the assessment of ice-recrystallization inhibition activity and subsequent isolation of native IBPs using ice-affinity purification.
FAQs
An inhibitor can adsorb onto a crystal surface and occupy active growth sites. This coverage interferes with the attachment of additional molecules to the lattice, reducing the rate at which existing crystals enlarge or coarsen. In chemistry, the effectiveness of this mechanism depends on how the additive interacts with the crystal surface and how completely it blocks accessible sites.
Additives can alter the solution surrounding a crystal, which changes molecular transport to the lattice. When fewer molecules reach the crystal surface or their incorporation becomes less favorable, crystal growth and coarsening slow. This solution-mediated mechanism complements surface adsorption and helps explain why different inhibitors can control crystal structure through more than one chemical pathway.
The two processes act at different stages. Recrystallization inhibition concerns crystals that have already formed and limits their nucleation, growth, or coarsening during subsequent changes in the system. This distinction matters because controlling post-formation enlargement can preserve a material’s structure even when initial crystal formation has not been completely eliminated.
Temperature fluctuations are especially relevant to ice because they can promote changes in crystal size after freezing. Inhibitors such as antifreeze proteins, polymers, and other additives limit the enlargement of ice crystals under these changing conditions. The resulting control is important when crystal size influences the stability or texture of a frozen material.
Evaluation focuses on whether the additive limits crystal enlargement or coarsening after crystals have formed, particularly during relevant temperature changes. Chemists can relate the observed crystal behavior to the proposed mechanism, such as surface adsorption or altered molecular transport. This assessment helps identify additives that provide useful structural control for a specific material system.
The concept supports the design of cryopreservation media, frozen foods, pharmaceuticals, and advanced materials. In cryopreservation and food systems, limiting ice-crystal enlargement can help maintain desirable structure and texture. In pharmaceuticals and advanced materials, controlling crystal development can contribute to improved stability and performance, making inhibition relevant across several chemistry-based applications.