Frostbite

Frostbite is a cold-related injury in which tissues freeze after exposure to low temperatures, making it an important clinical emergency because it can cause lasting damage to skin, nerves, muscle, and blood vessels. Freezing forms ice crystals within and around cells, while vasoconstriction and reduced blood flow produce ischemia; thawing can then trigger inflammation, swelling, and reperfusion injury. Clinical assessment focuses on exposure history, tissue appearance, sensation, and perfusion, while management prioritizes removal from the cold, careful rewarming when refreezing is unlikely, wound protection, and evaluation for deeper injury. Prompt care can limit tissue loss and guide later surgical decisions.

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Research

JoVE Journal - Medicine

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

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2025

Overtreatment is often administered to patients with low-risk prostate cancer; super-active surveillance can help avoid such overtreatment.

Education

JoVE Science Education - Basic Biology

Working with Hot and Cold Sources

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2023

Source: Robert M. Rioux & Suprita Jharimune, Pennsylvania State University, University Park, PA Working with extreme temperatures, both high and low, is an integral part of many laboratory operations. For many, mentioning a laboratory instantly evokes the mental picture of a Bunsen burner. Bunsen burners and hot plates are used extensively in small and large operations in research laboratories and industries, thus making it necessary for all users to be aware of their safe handling...

Conducting Reactions Below Room Temperature

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2023

Source: Laboratory of Dr. Dana Lashley - College of William and Mary Demonstration by: Matt Smith When new bonds are formed in the course of a chemical reaction, it requires that the involved species (atoms or molecules) come in very close proximity and collide into one another. The collisions between these species are more frequent and effective the higher the speed at which these molecules are moving. A widely used rule of thumb, which has its roots in the Arrhenius equation1, states that...

Research

JoVE Journal - Medicine
Free Sample

Induction of Myocardial Infarction in Adult Zebrafish Using Cryoinjury

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Cited by 63 •

2012

Zebrafish represents a valuable model to study the mechanisms of heart regeneration in vertebrates. Here, we present a protocol for induction of a heart infarct in adult zebrafish using cryoinjury. This method results in massive cell death within 20% of the ventricular wall, similar to that observed in mammalian infarcts.

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