Ultrasound Contrast Imaging
Ultrasound Contrast Imaging - Related Videos
10:39
Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound
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Cited by 4 •
2015
Here, we present a protocol to inject ultrasound microbubble contrast agents into living, isolated late-gestation stage murine embryos. This method enables the study of perfusion parameters and of vascular molecular markers within the embryo using contrast-enhanced high-frequency ultrasound imaging.
09:19
Contrast Enhanced Ultrasound Imaging for Assessment of Spinal Cord Blood Flow in Experimental Spinal Cord Injury
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Cited by 16 •
2015
Contrast Enhanced Ultrasound imaging is a reliable in-vivo tool for quantifying spinal cord blood flow in an experimental rat spinal cord injury model. This paper contains a comprehensive protocol for application of this technique in association with a contusion model of thoracic spinal cord injury.
05:50
Contrast Enhanced Vessel Imaging using MicroCT
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Cited by 17 •
2011
Contrast enhanced small animal vessel imaging by microCT is a rapid, cost-effective and high-throughput technique for serial in situ examination for tumor development, for analyzing the network of blood vessels that nourish them, and for following the response of tumors to preclinical therapeutic intervention(s).
10:53
A Novel Application of Musculoskeletal Ultrasound Imaging
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Cited by 14 •
2013
We describe a new ultrasound-based vector tissue Doppler imaging technique to measure muscle contraction velocity, strain and strain rate with sub-millisecond temporal resolution during dynamic activities. This approach provides complementary measurements of dynamic muscle function and could lead to a better understanding of mechanisms underlying musculoskeletal disorders.
14:20
High-frequency Ultrasound Imaging of the Abdominal Aorta
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2023
Source: Amelia R. Adelsperger, Evan H. Phillips, and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana High-frequency ultrasound systems are used to acquire high resolution images. Here, the use of a state-of-the-art system will be demonstrated to image the morphology and hemodynamics of small pulsatile arteries and veins found in mice and rats. Ultrasound is a relatively inexpensive, portable, and versatile method for the noninvasive...
FAQs
The gas-filled microbubbles respond to the applied ultrasound field by oscillating. Their movement strongly scatters sound back toward the imaging system, creating brighter signals than may be produced by surrounding structures or fluids alone. This enhanced backscatter helps distinguish features that are difficult to separate on standard ultrasound scans, particularly when tracking circulation-related changes.
Because the contrast agents travel within the circulation, their enhanced signals follow the movement of blood through the imaged region. Signal changes can therefore reflect blood flow and tissue perfusion rather than only anatomical appearance. This distinction is useful when developmental studies need to relate changing structure to the physiological delivery of circulating blood.
Real-time imaging allows researchers to observe physiological and structural changes as they occur in a living embryo or model organism. It can provide repeated observations while reducing the need for invasive sampling at each time point. This supports analysis of developmental dynamics, including changes that might be missed when observations rely only on separate endpoint samples.
In developmental biology, the method can support monitoring of vascular formation, organ development, and associated physiological changes. Enhanced signals may help researchers follow how blood flow or perfusion changes as tissues and organs develop. Its value is greatest when the study requires observations within living embryos or model organisms rather than isolated material.
The enhanced signals can reveal structures and fluid movement that are difficult to distinguish in standard scans. They also provide information related to blood flow and tissue perfusion, allowing structural and physiological observations to be considered together. This combination can help characterize developmental changes more completely than an image focused only on anatomy.
Its noninvasive character and real-time capability make repeated observation of living subjects more practical. Researchers can monitor developmental progression, vascular formation, organ development, and physiological change without relying exclusively on repeated invasive sampling. The resulting time-resolved observations can show developmental dynamics across successive examinations rather than only a single stage.