Arterial Permeation
Arterial Permeation - Related Videos
01:58
Studying the Permeation of FITC and FITC-Ferritin through an In Vitro Blood-Brain Barrier Model
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2025
This video demonstrates a method to study permeation through an in vitro blood-brain barrier (BBB) model using astrocytes and endothelial cells on a membrane insert, with free FITC and FITC-loaded ferritin. FITC-ferritin bound to receptors on endothelial cells and crossed the membrane barrier to the lower chamber while free FITC showed restricted permeation and remained in the upper chamber.
11:13
In Vitro Permeation of FITC-loaded Ferritins Across a Rat Blood-brain Barrier: a Model to Study the Delivery of Nanoformulated Molecules
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Cited by 15 •
2016
A method to establish an in vitro model of blood-brain barrier based on a co-culture of rat brain microvascular endothelial cells and astrocytes is described and validated. This system proved to be a valid tool to study the effect of nanoformulation on the trans-barrier permeation of fluorescent molecules.
06:57
Arterial Line Placement
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2023
Source: Sharon Bord, MD, Department of Emergency Medicine, The Johns Hopkins University School of Medicine, Maryland, USA When monitoring patients, it is important to obtain values that are accurate and reliable. Blood pressure monitoring is one of the essential vital signs, and for a majority of patients, measuring it utilizing non-invasive techniques provides accurate values. However, there are situations in which the blood pressure requires more exact, specific, and reliable measurements.
05:54
Controlled Odor Mimic Permeation Systems for Olfactory Training and Field Testing
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Cited by 1 •
2021
The Controlled Odor Mimic Permeation System is a simple, field-portable, low-cost method of odor delivery for olfactory testing and training. It is constructed of an odorant retained on an adsorbent material and contained inside of a permeable polymer bag allowing controlled release of the odorant vapor over time.
13:10
Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery (ALCAPA)
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Cited by 7 •
2017
Surgical correction of ALCAPA is highly recommended, regardless of age or the degree of intercoronary collateralization. This protocol presents a technique for the direct re-implantation of adult-type ALCAPA into the aorta to re-establish the dual-coronary perfusion. Whenever feasible, direct re-implantation is preferred to other surgical correction techniques.
FAQs
Molecular size and lipid solubility help determine how readily substances cross the arterial wall. Smaller molecules may encounter fewer restrictions, while lipid solubility affects interactions with the endothelial lining and vessel layers. These properties are therefore important when comparing how solutes, drugs, or macromolecules distribute within arterial tissue and when evaluating potential delivery strategies.
Pressure gradients provide a physical factor that can influence movement across the arterial wall. Their effect operates alongside endothelial permeability and the properties of the transported substance, rather than acting independently. Accounting for these gradients helps researchers interpret variation in arterial transport and develop models that better represent conditions relevant to vascular function and treatment delivery.
Inflammation and vascular injury can change the properties of the arterial wall, including the behavior of its endothelial lining and underlying layers. Such changes may modify how substances enter or accumulate within the vessel wall. This relationship is important in cardiovascular research because altered transport can help explain the distribution of atherosclerotic factors in diseased arteries.
Measurement and modeling focus on how fluids, solutes, drugs, or macromolecules move across the arterial wall under relevant biological conditions. Researchers can examine the influence of molecular size, lipid solubility, pressure gradients, endothelial permeability, and vascular changes. These approaches support interpretation of transport behavior and help predict how substances may reach or accumulate in arterial tissue.
Arterial permeation helps explain how factors associated with atherosclerosis enter and accumulate within vessel walls. Their movement is influenced by wall permeability and by changes linked to inflammation or vascular injury. Studying this process connects transport behavior with the development of arterial disease, providing a basis for investigating how diseased tissue forms and responds to treatment.
The process helps researchers evaluate whether therapeutic agents can reach diseased arterial tissue and how their transport may be affected by molecular properties, pressure gradients, and vascular condition. This information supports the design and assessment of treatment-delivery strategies. It also contributes to broader cardiovascular research and to developing therapies directed at arterial disease.