Autologous Blood Injection
Autologous Blood Injection - Related Videos
10:44
Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase
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Cited by 60 •
2012
Clinically relevant animal models of intracerebral hemorrhage (ICH) are needed to extend our knowledge of hemorrhagic stroke and to examine novel therapeutic strategies. In this study, we describe and evaluate two ICH models that implement unilateral injections of either autologous whole blood or bacterial collagenase into the basal ganglia (corpus striatum) of mice.
07:02
Autologous Blood Injection to Model Spontaneous Intracerebral Hemorrhage in Mice
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Cited by 28 •
2011
The autologous blood injection model of intracerebral hemorrhage in mice described in this protocol uses the double injection technique to minimize risk of blood reflux up the needle track, no anticoagulants in the pumping system, and eliminates all dead space and expandable tubing in the system.
09:41
Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage
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Cited by 35 •
2014
Preclinical models of intracerebral hemorrhage are utilized to mimic certain aspects of clinical disease. Thus, mechanisms of injury and potential therapeutic strategies may be explored. In this protocol, two models of intracerebral hemorrhage are described, intrastriatal (basal ganglia) injections of autologous blood or collagenase.
04:38
Inducing Massive Pontine Hemorrhage in a Rat Model by Autologous Blood Injection
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2025
Source: Tang, X. et. al., Massive Pontine Hemorrhage by Dual Injection of Autologous Blood. J. Vis. Exp. (2021)This protocol describes the controlled infusion of autologous blood into the pontine region of a rat's brain to model massive pontine hemorrhage. The purpose is to simulate a localized brain bleed by increasing localized pressure.
04:35
Establishing a Subarachnoid Hemorrhage Rat Model Induced by Autologous Blood Injection
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2025
This video demonstrates the procedure for establishing a subarachnoid hemorrhage rat model. An anesthetized rat is implanted with probes to measure intracranial pressure and cerebral blood flow. The target site is identified, and the needle is inserted at a pre-chiasmatic position. Autologous blood is then injected into the subarachnoid space, increasing intracranial pressure and decreasing cerebral blood flow, establishing the model.
FAQs
The injected blood may create a localized inflammatory response that supports healing-related activity. Blood components can contribute to cell recruitment and subsequent tissue remodeling at the treatment site. These effects are intended to modify the local tissue environment rather than simply mask symptoms, although the resulting benefit may differ according to the underlying disorder and the site receiving treatment.
Using the patient’s own blood reduces exposure to donor-derived material, which is a central rationale for the approach. The material being injected originates from the same individual receiving treatment, while its local biological effects are studied in the targeted tissue. This feature distinguishes the procedure from approaches that depend on blood or blood components obtained from another person.
Treatment site, injection technique, and the underlying disorder can all influence results. A response observed near an injured tendon may not predict what occurs in a joint-related pain condition or another chronic soft-tissue problem. Because these variables can affect both biological response and clinical outcome, studies must evaluate the procedure in clearly defined conditions rather than assuming one result applies broadly.
The procedure begins with withdrawing a sample of the patient’s blood. Clinicians then reinject that blood into a targeted tissue or symptomatic site, such as near an injured tendon in musculoskeletal care. The intended effect depends on accurate selection of the treatment location and the injection approach, making technique an important part of how the intervention is evaluated.
Medical investigations have examined this approach in tendinopathies, joint-related pain, and other chronic soft-tissue conditions. In musculoskeletal care, the target may be tissue near an injured tendon or another symptomatic area. These applications reflect an effort to support local healing, but the available outcome can vary by condition, so use in one disorder does not establish effectiveness for another.
Controlled studies are important because outcomes may change with the treatment site, injection technique, and underlying disorder. Comparing results under defined conditions helps separate effects associated with the injection from changes related to the condition itself or the treatment context. This evidence is needed to clarify effectiveness and identify where the procedure has an appropriate role in medical care.