Congenital Heart Disease

Congenital heart disease is a group of structural abnormalities of the heart or great vessels that are present at birth and can alter circulation throughout life. These defects arise when the developing heart does not form normally, potentially disrupting blood flow, oxygen delivery, or pressure between cardiac chambers and vessels. In medicine, evaluation may include physical examination, echocardiography, electrocardiography, and other imaging to define anatomy and function. Management ranges from observation and medication to catheter-based procedures or surgery, depending on severity. Studying congenital heart disease improves early diagnosis, guides individualized care, and supports long-term monitoring from childhood through adulthood.

Congenital Heart Disease - Related Videos

Research

JoVE Journal - Medicine
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Implantation of Total Artificial Heart in Congenital Heart Disease

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Cited by 40 •

2014

This is a case report of a patient with congenitally corrected transposition of the great arteries (CCTGA) who received a total artificial heart (TAH) as a bridge to heart transplant. The TAH was successfully implanted with modifications to accommodate the patient's congenitally malformed heart.

Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model

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Cited by 12 •

2012

The inoculation of Trypanosoma cruzi in fertile eggs prior to incubation renders the parasite kDNA minicircle integration in embryo cells genome. Crossbreeding reveals the vertical transfer of the mutations to progeny. The kDNA integrates into coding regions at several chromosomes and the chickens die with an inflammatory autoimmune heart disease.

Education

JoVE Core - Medical-Surgical Nursing

Rheumatic Heart Disease I: Introduction

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2025

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods

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Cited by 4 •

2020

In this protocol, we describe procedures to qualitatively and quantitatively analyze developmental phenotypes in mice associated with congenital heart defects.

Ischemic Heart Disease: Overview

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2024

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction. Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...

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