Patient Discomfort

Patient discomfort is a subjective experience of physical or emotional unease that can signal illness, injury, treatment effects, or unmet care needs. When tissue damage or inflammation occurs, nociceptors detect potentially harmful stimuli and transmit signals through the nervous system to the brain, where sensation is shaped by psychological and environmental factors. In medicine, clinicians assess discomfort through patient descriptions, behavioral cues, and changes over time, including when communication is limited. This assessment supports diagnosis, guides pain relief and other symptom-management strategies, improves procedural care, and helps evaluate treatment effectiveness and patient-centered outcomes.

Patient Discomfort - Related Videos

Education

JoVE Science Education - Clinical Skills

Proper Adjustment of Patient Attire during the Physical Exam

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2023

Source: Jaideep S. Talwalkar, MD, and Joseph Donroe, MD, Internal Medicine and Pediatrics, Yale School of Medicine, New Haven, CT In order to optimize the predictive value of the physical examination, the provider must perform maneuvers correctly. The proper use of drapes is an important component of correctly performing physical examination maneuvers. Skin lesions are missed when "inspection" occurs through clothing, crackles are erroneously reported when the lungs are examined through a...

Research

JoVE Journal - Medicine

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

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Cited by 10 •

2017

This protocol was developed to quantitatively identify tumor microenvironment components in glioblastoma patient resections using chromogenic immunohistochemistry and ImageJ.

Methyl-binding DNA capture Sequencing for Patient Tissues

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Cited by 1 •

2016

Here we present a protocol to investigate genome wide DNA methylation in large scale clinical patient screening studies using the Methyl-Binding DNA Capture sequencing (MBDCap-seq or MBD-seq) technology and the subsequent bioinformatics analysis pipeline.

Assessment of Vascular Function in Patients With Chronic Kidney Disease

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Cited by 25 •

2014

The degree of vascular dysfunction and contributing physiological mechanisms can be assessed in patients with chronic kidney disease by measuring brachial artery flow-mediated dilation, aortic pulse-wave velocity, and vascular endothelial cell protein expression.

Research

JoVE Journal - Medicine
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Isolation of Human Islets from Partially Pancreatectomized Patients

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Cited by 10 •

2011

The supply of type 2 diabetic islets for research is insufficient. Here we share our protocol for isolating islets from patients undergoing partial pancreatectomy. This approach represents a unique venue for obtaining islets from type 2 diabetic and clinically matched non-diabetic subjects in adequate numbers for basic and clinical studies.

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