Ventilator-induced Injury
Ventilator-induced Injury - Related Videos
07:55
Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice
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Cited by 7 •
2011
A murine model for ventilator induced lung injury is an important tool to study an acute lung injury in vivo. Here, we report an easy applicable in situ model for acute lung injury using high-pressure mechanical ventilation to induce acute failure of the lung.
05:05
A Structured Approach to Extubation in Mechanically Ventilated Rats
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2025
This study proposes a structured extubation approach tailored to rat models of mechanical ventilation (MV). The approach facilitates a smooth transition from MV to spontaneous breathing while minimizing extubation-related complications. Standardization of weaning, airway management, and post-extubation care enhances the reliability and reproducibility of experimental studies.
03:34
Inducing a Facial Nerve Injury in a Rat Model
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2025
This video demonstrates a surgical protocol on a rat model, detailing steps from anesthesia preparation to facial nerve injury induction. This protocol is useful for studying nerve regeneration and surgical techniques in medical research.
02:30
Performing Laser-Induced Brain Injury in a Rat Model
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2025
This video demonstrates a procedure to generate precise, controlled brain injury in the rat motor cortex using a laser.
01:23
Mechanical Ventilation II: Invasive Ventilation
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2025
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators. Negative-Pressure Ventilators Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
FAQs
Mechanical stress arises when ventilation exposes lung tissue to excessive tidal volumes or airway pressures. Repeated collapse and reopening adds a separate cycle of tissue strain. These stresses can coexist, so adjusting only one variable may not address every pathway of damage. Their interaction is why ventilation settings require coordinated adjustment.
Biotrauma refers to inflammatory signaling triggered by mechanical ventilation-related injury. It links physical stresses, including overstretch and repetitive alveolar motion, with a biological response that can worsen lung damage. This mechanism matters clinically because ventilator management aims not only to limit pressure- or volume-related stress, but also to reduce its inflammatory consequences.
Barotrauma and volutrauma describe different mechanical contributors within the broader injury pattern: one is associated with excessive airway pressure, whereas the other is associated with excessive tidal volume. Repetitive collapse and reopening represents another damaging process rather than simply a pressure or volume setting. Distinguishing these contributors helps clinicians consider pressure, volume, and PEEP together.
Positive end-expiratory pressure, or PEEP, is one of the variables used in lung-protective ventilation. Its inclusion reflects the need to address repetitive alveolar collapse and reopening while selecting settings that do not add excessive mechanical stress. In practice, PEEP is considered alongside tidal volume and pressure limits rather than treated as an isolated control.
The strategy requires deliberate selection of tidal volume, airway-pressure limits, and positive end-expiratory pressure. These settings are considered together to reduce overstretch and repetitive collapse and reopening. The central procedure is therefore not a single adjustment, but coordinated ventilator management directed at limiting additional lung damage during respiratory support.
It is especially relevant during care of critically ill patients with respiratory failure who require mechanical ventilation. In this setting, ventilation can become an additional source of lung damage, so clinicians use lung-protective principles to guide settings. The approach supports intensive-care decision-making while addressing the risk that respiratory support may worsen existing injury.
Studying ventilator-induced injury can improve ventilator management and inform safer respiratory-support strategies. Mechanistic knowledge clarifies how tidal volume, airway pressure, repetitive alveolar collapse and reopening, and inflammatory signaling contribute to harm. That information connects bedside intensive-care practice with research aimed at reducing additional damage in patients already experiencing respiratory failure.