Core Temperature Maintenance

Core temperature maintenance is the physiological regulation of internal body temperature within a narrow range, a process essential for stable brain function and survival. In mammals, temperature-sensitive neurons and peripheral receptors relay information to the hypothalamus, which compares body temperature with a regulated set point and coordinates responses such as vasoconstriction, shivering, sweating, and changes in metabolic heat production. Neuroscience research uses this process to examine hypothalamic circuits, autonomic control, sleep, fever, and responses to environmental stress. Understanding these mechanisms helps clarify how neural systems preserve homeostasis and why disrupted thermoregulation accompanies infection, neurological disease, anesthesia, and injury.

Core Temperature Maintenance - Related Videos

Research

JoVE EoE - Rodent Models

Surgical Implantation of Temperature Telemetric Monitoring System in Mouse Model: A Surgical Procedure to Implant Temperature Telemetric Device to Measure Mouse Core Body Temperature

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2025

In this video, we describe a surgical procedure to implant a temperature telemetric device in a mouse model to continuously measure its core body temperature.

Education

JoVE Science Education - Basic Biology

Drosophila Maintenance

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2023

Drosophila melanogaster, commonly known as fruit flies, are a frequently used model organism for life science research. Although starting a collection of these critters may seem as easy as leaving a banana on your kitchen counter for too long, a productive fly colony in the lab requires careful husbandry and maintenance. This video demonstrates the necessary steps for maintaining a healthy fly stock. The overview begins with the preparation and storage of the yeast and sugar-containing media on...

Research

JoVE Journal - Medicine
Free Sample

Implantation of Radiotelemetry Transmitters Yielding Data on ECG, Heart Rate, Core Body Temperature and Activity in Free-moving Laboratory Mice

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Cited by 56 •

2011

A surgical technique for implantation of commercially available telemetry transmitters used for continuous measurement of biopotential (one-lead ECG), heart rate, core body temperature and locomotor activity in freely moving mice is shown. Recommendations and protocols for post-operative care and pain relief, improving recovery, well being and survival rate are also presented.

C. elegans Maintenance

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2023

Ceanorhabditis elegans has been, and is still, used to great success as a model organism for studying a variety of developmental, genetic, molecular and even physical phenomena. In order to use C. elegans to its full potential, proper care and attention to the basic maintenance of this powerful organism is essential. In this video you will learn the basic housing and feeding requirements of C. elegans, how to correctly handle and manipulate worms using a worm pick and how to freeze and recover...

The Nucleosome Core Particle

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2020

Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins. The paradox Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...

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