Cyclic Olefin Copolymer Chips
Cyclic Olefin Copolymer Chips - Related Videos
08:37
Cyclic Voltammetry (CV)
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2023
Source: Laboratory of Dr. Kayla Green — Texas Christian University A Cyclic Voltammetry (CV) experiment involves the scan of a range of potential voltages while measuring current. In the CV experiment, the potential of an immersed, stationary electrode is scanned from a predetermined starting potential to a final value (called the switching potential) and then the reverse scan is obtained. This gives a 'cyclic' sweep of potentials and the current vs. potential curve derived from the data is...
10:53
Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
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Cited by 2 •
2016
The key steps of living anionic polymerization of phenyl glycidyl ether (PheGE) on methoxy-polyethylene glycol (mPEG-b-PPheGE) are described. The resulting block copolymer micelles (BCMs) were loaded with doxorubicin 14% (wt%) and sustained release of drug over 4 days under physiologically relevant conditions was obtained.
09:15
Synthesis of Ligand-free CdS Nanoparticles within a Sulfur Copolymer Matrix
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2016
Herein we present a method to synthesize ligand-free cadmium sulfide (CdS) nanoparticles based on a unique sulfur copolymer. The sulfur copolymer operates as a high temperature solvent and a sulfur source during the nanoparticle synthesis and stabilizes the nanoparticles after the reaction.
01:35
Organ-on-Chip Models
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2026
Introduction to Organ-on-Chip Models Organ-on-chip models are advanced microphysiological systems that recreate key structural and functional features of human organs in a controlled laboratory setting. These devices integrate living human cells within microfluidic channels, allowing researchers to simulate tissue–tissue interfaces, fluid flow, and mechanical forces that are essential for normal organ function. Unlike traditional cell cultures, which often lack these dynamic physiological cues,...
05:33
Solid-state Graft Copolymer Electrolytes for Lithium Battery Applications
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2013
Lithium ion batteries employ flammable and volatile organic electrolytes that are suitable for ambient temperature applications. A safer alternative to organic electrolytes are solid polymer batteries. Solid polymer batteries operate safely at high temperatures (>120 °C), thus making them applicable to high temperature applications such as deep oil drilling and hybrid electric vehicles. This paper will discuss (a) the polymer synthesis, (b) the polymer conduction mechanism, and (c) provide...
FAQs
Patterned microchannels direct fluids through either pressure-driven flow or capillary flow, allowing researchers to regulate how solutions contact cultured cells or tissues. Because the channels contain small volumes, changes in the chemical environment can be controlled with relatively little reagent. This supports reproducible experiments in which neural samples experience defined fluid conditions.
Optical clarity allows researchers to image cells and tissues through the chip, while low autofluorescence reduces background signal produced by the device itself. Together, these properties support high-resolution visualization of neuronal cultures, synaptic features, and tissue responses. The resulting images can make cellular changes easier to observe and interpret during controlled experiments.
The thermoplastic material combines chemical resistance with optical transparency, helping the chip withstand contact with experimental solutions while remaining suitable for imaging. These characteristics are especially useful when experiments require repeated observation of living neural samples under defined conditions. The material platform therefore supports both environmental control and visualization within the same device.
Small internal volumes improve control over the chemical environment surrounding cells and tissues and reduce the amount of reagent required. This can help investigators expose neural cultures to defined experimental conditions while limiting resource use. In neuroscience studies, that control is relevant for examining development, disease-related responses, drug effects, and interactions between different cell types.
A supported workflow begins by placing neuronal cultures or tissue models within the chip’s patterned microchannels, followed by establishing fluid movement through pressure or capillary forces. Researchers can then maintain the controlled microenvironment and use the chip’s optical properties to image the sample. This sequence links fluid handling, biological exposure, and direct observation in one experiment.
Applications include neuronal cultures, synaptic studies, brain-on-chip models, and investigations of barriers such as the blood-brain barrier. These formats allow researchers to examine neural cells or interacting tissues under controlled microchannel conditions. Depending on the model, the chip can support questions about neural development, cell communication, disease mechanisms, or responses to candidate treatments.
Cyclic Olefin Copolymer Chips can help researchers examine cellular behavior, synaptic processes, barrier-related phenomena, disease mechanisms, and drug responses. Their controlled conditions and imaging compatibility support observation of changes in cells and tissues during an experiment. By reducing reagent use and improving experimental reproducibility, they also provide a practical platform for studying complex neural interactions.