Flexible Probe Implantation
Flexible Probe Implantation - Related Videos
03:47
Implantation of a Flexible Biocompatible Probe in a Glioblastoma Mouse Model
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2025
Source: Lefevre, M. C., et al., Flexible Organic Electronic Devices for Pulsed Electric Field Therapy of Glioblastoma. J. Vis. Exp. (2022)This video demonstrates the implantation of a flexible, biocompatible probe in a glioblastoma mouse model to deliver targeted pulsed electric field therapy for neurotherapeutic applications.
06:40
Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive
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Cited by 99 •
2013
Insertion of flexible neural microelectrode probes is enabled by attaching probes to rigid stiffeners with polyethylene glycol (PEG). A unique assembly process ensures uniform and repeatable attachment. After insertion into tissue, the PEG dissolves and the stiffener is extracted. An in vitro test method evaluates the technique in agarose gel.
02:22
Positioning Laser Doppler Probe: A Technique to Implant Probe Over Middle Cerebral Artery for Blood Flow Measurement in Murine Model
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2025
This video describes the surgical procedure to immobilize the laser Doppler probe over the murine brain's middle cerebral artery, or MCA. The probe helps to measure the blood flow in the brain's microvasculature by measuring the Doppler shift caused due to the motion of red blood cells within the artery.
08:54
Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
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Cited by 24 •
2019
Described below is a method for implantation of multiple polymer electrode arrays across anatomically distant brain regions for chronic electrophysiological recording in freely moving rats. Preparation and surgical implantation are described in detail, with emphasis on design principles to guide adaptation of these methods for use in other species.
17:37
Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents
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Cited by 111 •
2012
We describe methods for large-scale recording of multiple single units and local field potential in behaving rodents with silicon probes. Drive fabrication, probe attachment to the drive and probe implantation processes are illustrated in sufficient details for easy replication.
FAQs
A soft probe can conform more closely to movement within neural tissue than a rigid device. This mechanical compatibility supports a more stable interface between the implanted array or sensor and the surrounding tissue. In turn, researchers can pursue measurements over longer periods while studying changing neural activity in living organisms.
Stable interfaces help implanted devices maintain contact with neural tissue during recording or stimulation. That stability matters because the technique is intended to monitor electrical signals or deliver modulation over time. By supporting longer-term measurements, flexible systems can improve the consistency and usefulness of information collected from neural circuits and behavior.
The key distinction is mechanical behavior: flexible probes bend and conform more closely to tissue movement, whereas rigid devices do not provide the same degree of conformity. This difference is central to the approach because it is linked to stable neural interfaces, longer-term measurements, and efforts to improve the compatibility and durability of implanted devices.
The procedure places a soft electrode array or sensor device into a selected neural target region. Once positioned, the probe can support either electrical recording, neural stimulation, or both, depending on the device and study. Its subsequent role is to monitor or modulate brain activity while remaining compatible with movement in living tissue.
These implants support studies of neural circuits, behavior, and neurological disease. Researchers can relate recorded electrical activity or applied stimulation to activity in targeted brain regions and to observable behavioral outcomes. Because the approach enables longer-term measurements, it is also suited to examining neural function across extended periods in living organisms.
Flexible implanted arrays and sensors contribute to brain-computer interfaces by providing implanted access to neural activity through recording or modulation. Their closer conformity to tissue movement, along with goals of improved durability, compatibility, and information quality, supports development of neurotechnologies that connect neural signals with engineered systems.