Voltage-sensing Biosensor
Voltage-sensing Biosensor - Related Videos
12:20
Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions
0 Views •
Cited by 7 •
2013
We describe the device fabrication and measurement protocol for carbon nanotube based high frequency biosensors. The high frequency sensing technique mitigates the fundamental ionic (Debye) screening effect and allows nanotube biosensor to be operated in high ionic strength solutions where conventional electronic biosensors fail. Our technology provides a unique platform for point-of-care (POC) electronic biosensors operating in physiologically relevant conditions.
05:15
Target Peptide Detection and Measurement Using a Capacitive Immunoprobe Biosensor
0 Views •
2025
This video demonstrates a method for detecting and quantifying peptide transmitters using a capacitive immunoprobe biosensor. The functionalized electrode, coated with antibodies, interacts with peptides of interest, leading to a signal change that allows precise measurement and detection of peptides.
04:17
Approximate Number Sense Test
0 Views •
2023
Source: Laboratory of Jonathan Flombaum—Johns Hopkins University A common carnival game is to ask people to guess the number of jellybeans packed into a jar. The chances that anyone will get the exact number right are low. But what about the chances that someone will guess 17 or 147,000? Probably even less than the chances of guessing the correct answer; 17 and 147,000 just seem irrational. Why? After all, if the beans cannot be taken out and counted one-at-a-time, how can someone tell that an...
08:19
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
0 Views •
Cited by 34 •
2012
This article details the construction of a multiplexed microneedle-based sensor. The device is being developed for in situ sampling and electrochemical analysis of multiple analytes in a rapid and selective manner. We envision clinical medicine and biomedical research uses for these microneedle-based sensors.
05:15
The Rouge Test: Searching for a Sense of Self
0 Views •
2023
Source: Laboratories of Nicholaus Noles and Judith Danovitch—University of Louisville Humans are different from other animals in many ways, but one of the abilities that sets humans apart is their advanced ability to understand other people and simulate their thoughts and feelings, even when the thoughts and feelings do not align with their own. In scientific terms, these abilities are referred to as theory of mind, and this understanding is necessary for activities like giving compliments,...
FAQs
The sensing event begins when a membrane-voltage shift alters the voltage-sensitive protein. That conformational change can modify the protein’s fluorescent properties, producing an optical signal that tracks electrical activity. Because the signal is linked to changes in protein state, the biosensor can report voltage dynamics in neuronal systems rather than merely indicating whether a cell is active.
Voltage-sensing biosensors can provide either optical or electrical outputs, depending on how the voltage-dependent change is measured. Optical readouts are especially useful when researchers need activity information from individual neurons or neural networks with spatial detail. Electrode recordings remain a related approach, but the biosensor adds a way to visualize voltage changes and complement measurements based solely on electrodes.
Depolarization and repolarization provide distinct parts of the voltage trajectory that a biosensor can follow. Recording both directions helps researchers examine how neuronal electrical activity rises and returns toward its prior state. The same approach can also capture subthreshold voltage dynamics, which occur without the full action potential described in the overview, broadening analysis of neuronal signaling.
A key advantage of Voltage-sensing Biosensor measurements is spatially resolved observation. Researchers can examine voltage behavior in a single neuron or compare activity across a neural network, allowing electrical events to be related to cellular or circuit organization. This scale of observation is important for connecting local membrane changes with broader patterns of neural communication and circuit function.
An experiment can be organized around observing neuronal activity and recording the resulting optical or electrical signal. Researchers can then examine responses associated with depolarization, repolarization, action potentials, or subthreshold dynamics. The workflow supports measurements at either the individual-cell level or across neural networks, depending on whether the study focuses on cellular behavior or coordinated circuit activity.
Applications include investigating synaptic signaling, neural circuit function, and neurological disease. By reporting voltage changes in real time and with spatial detail, these sensors help connect electrical events at the membrane with communication between neurons and activity across networks. Their use therefore extends from basic studies of neuronal signaling to research examining altered activity associated with disease.