Spatiotemporal Maps
Spatiotemporal Maps - Related Videos
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Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines
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Cited by 26 •
2016
Recently available video recording and spatiotemporal mapping (STmap) techniques make it possible to visualize and quantify both propagating and mixing patterns of intestinal motility. The goal of this protocol is to explain the generation and analysis of STmaps using the GastroIntestinal Motility Monitoring (GIMM) system.
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Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
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Cited by 63 •
2016
This article describes a video imaging technique and high-resolution spatiotemporal mapping to identify changes in the neural regulation of colonic motility in adult mice. Subtle effects on gastrointestinal (GI) function can be detected using this approach in isolated tissue preparations to advance our understanding of GI disease.
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Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
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Cited by 6 •
2017
The fission yeast, Schizosaccharomyces pombe is an excellent model system to study cytokinesis, the final stage in cell division. Here we describe a microscopy approach to analyze different cytokinetic events in live fission yeast cells.
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Fate Mapping
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2023
Fate mapping is a technique used to understand how embryonic cells divide, differentiate, and migrate during development. In classic fate mapping experiments, cells in different areas of an embryo are labeled with a chemical dye and then tracked to determine which tissues or structures they form. Technological improvements now allow for individual cells to be marked and traced throughout embryonic development and adulthood. This video reviews the concepts behind fate mapping, and then details a...
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Motor Maps
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2023
Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California One principle of brain organization is the topographic mapping of information. Especially in sensory and motor cortices, adjacent regions of the brain tend to represent information from adjacent parts of the body, resulting in maps of the body expressed on the surface of the brain. The primary sensory and motor maps in the brain surround a prominent sulcus known as the central sulcus. The cortex...
FAQs
Interpretation depends on aligning spatial coordinates with time-resolved measurements. A map can show whether a change in drug concentration, tissue distribution, receptor activity, or response occurs in the same anatomical region and at the same or different time points. This alignment helps distinguish where a pharmacological event occurs from when it develops, persists, or declines.
Linking pharmacokinetics and pharmacodynamics is a central interpretive use. Concentration patterns describe exposure across regions and times, whereas receptor activity or measured response indicates biological effect. Comparing these layers can reveal whether an anatomical site experiences drug exposure together with the expected action, or whether distribution and response are separated in space or time.
Map quality is shaped by the choice of anatomical regions and time points. Finer regional sampling can distinguish different tissue locations, while multiple time points can capture changing absorption, transport, metabolism, and clearance. Dose and formulation comparisons add another dimension, allowing investigators to examine how those choices alter concentration, distribution, or response patterns.
Unlike a single concentration measurement or a purely spatial distribution image, a spatiotemporal map preserves the relationship between location and progression over time. That added structure can expose transient exposure, delayed response, or changing clearance patterns that may be missed when measurements are considered separately. It therefore supports a more connected interpretation of drug behavior.
Creating a useful map begins by selecting the anatomical regions, biological measurements, and time points relevant to the pharmacological question. Researchers then organize measurements such as drug concentration, tissue distribution, receptor activity, and response across those coordinates. Visual comparison of the resulting patterns can connect exposure with effect and support comparisons between doses or formulations.
Formulation and dose studies can use these maps to compare how candidate treatments behave in vivo. Differences in regional concentration, tissue distribution, receptor activity, or response may indicate whether a formulation improves delivery to a desired site or changes the timing of exposure. The resulting comparison can inform treatment optimization and targeted drug-delivery strategies.
Mapping sites of drug action and toxicity helps pharmacologists evaluate benefit and risk in anatomical context. When response and adverse effects are placed alongside distribution and concentration, researchers can identify regions associated with intended activity or harmful exposure. These observations also contribute to more predictive models of therapeutic response, especially when timing is included.