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Bakteriell Leverans av RNAi Effektenheter: Transkingdom RNAi

Article DOI: 10.3791/2099-v • 07:57 min • August 18th, 2010
August 18th, 2010 •
1, 1
1Institute of Pathology, Charité Campus Mitte

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För utveckling av RNA-interferens (RNAi)-baserade terapier, var en roman strategi utvecklats, transkingdom RNAi (tkRNAi). Denna teknik använder icke-patogena bakterier att producera och leverera terapeutiska korta hårnål RNA (shRNA) i målceller. Här var tkRNAi framgång använts för återföring av klassisk ABCB1-medierad multidrogresistensgenen (MDR) av cancerceller.

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Mikrobiologi 42 Transkingdom RNAi shRNA genterapi cancer multidrogresistensgenen bakterier
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