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Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging

Article DOI: 10.3791/2775-v • 08:05 min • April 14th, 2011
April 14th, 2011 •
1, 1, 1, 1, 1, 1
1Imaging Biology Research and Development, Caliper Life Sciences

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An experimental mouse model of bone metastasis was established following intracardiac delivery of luciferase expressing mammary tumor cells. Tumor development and resulted osteolytic lesion were monitored longitudinally with bioluminescence and micro CT imaging.

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Tumor Metastases Osteolytic Lesions Bioluminescence Imaging Micro CT Imaging MDA-MB-231-luc-D3H2LN Cells Nu/Nu Mice Intracardiac Delivery Systemic Metastases IVIS Spectrum DLIT Reconstruction Tumor Signal Bone Tissues Tibia Femur Micro CT System Quantum FX X-ray Dose Radiation Dose LD50 Mouse Imaging Shuttle Device Animal Positioning Co-registration Living Image 4.1 Software
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