Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Matthias Ernst; Adele Preaudet; Tracy Putoczki

doi:10.3791/52383

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Valutazione non invasiva della efficacia di nuove terapie per patologie intestinali Utilizzando Serial Imaging endoscopica Live Mice

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

JoVE Journal
Medicina

This content is Free Access.

JoVE Journal Medicina

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Valutazione non invasiva della efficacia di nuove terapie per patologie intestinali Utilizzando Serial Imaging endoscopica Live Mice

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9,957 Views

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09:01 min

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March 10, 2015

DOI:

10.3791/52383-v

DOI:

10.3791/52383-v

•

09:01 min

March 10, 2015

•

6 Views

Matthias Ernst^1,2,3, Adele Preaudet¹, Tracy Putoczki^1,2

¹The Walter and Eliza Hall Institute for Medical Research, ²The Department of Medical Biology,University of Melbourne, ³Olivia Newton-John Cancer Research Institute

Summary

We describe methods for longitudinal monitoring of the efficacy of therapeutics for the treatment of colonic pathologies in mice using a rigid endoscope. This protocol can be readily used for the characterization of the therapeutic response of an individual tumor in live mice and also for monitoring potential disease relapse.